The purpose of Core A (Administrative Core) is to ensure scientific progress and promote synergy by providing scientific, organizational, and administrative leadership. This will be accomplished by extensive review of progress through monthly meetings of the laboratory groups and smaller meetings held by subgroups. Scientific direction and research results will be subject to intense, yet constructive, criticism by investigators with the POl, by an internal advisory group and by an outside advisory board.
The Aims of Core A are as follows:
Aim 1. To ensure scientific progress.
Aim 2. To implement statistical support.
Aim 3. To implement financial management and administrative support. Dr. Genco is the Project Director of the Program Project and will be administratively responsible together with Dr. Wetzler (the Associate Director) as a part of the Administrative Core for all aspects of the project. Dr. Michael LaValley will participate by advising investigators on study design, statistical analysis and interpretation of results. He will attend monthly project meetings to discuss design issues and interim analyses. He will also work with investigators to prepare statistical analysis for presentations and publications. Core A will provide administrative support to assist projects and in the interactions with Central Administration to facilitate accounting information, on institutional biosafety, animal use and human use issues. Core A will coordinate long range planning, organizing communication between Project leaders, Co-Investigators, and the In vitro Core and the Animal Core. The project leaders and Co-Investigators of the individual projects and the In Vitro and Animal Cores will meet twice per month and discuss research findings. At these meetings there will also be discussion for long-term goals of the projects and future directions. An internal advisory committee will meet twice per year. The purpose of this meeting will be for the 4 research projects directors to present an update on their research progress. An external advisory board that will meet once per year will also advise this Core. Core A will be responsible reviewing and funding new pilot projects from junior faculty, which are directly related to the proposed studies.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-PRJ-I)
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Boston University
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Shaik-Dasthagirisaheb, Y B; Huang, N; Weinberg, E O et al. (2015) Aging and contribution of MyD88 and TRIF to expression of TLR pathway-associated genes following stimulation with Porphyromonas gingivalis. J Periodontal Res 50:89-102
Huang, Nasi; Gibson 3rd, Frank C (2014) Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms. Curr Oral Health Rep 1:124-132
Koupenova, Milka; Vitseva, Olga; MacKay, Christopher R et al. (2014) Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood 124:791-802
Shaik-Dasthagirisaheb, Yazdani B; Huang, Nasi; Gibson 3rd, Frank C (2014) Inflammatory response to Porphyromonas gingivalis partially requires interferon regulatory factor (IRF) 3. Innate Immun 20:312-9
Beaulieu, Lea M; Lin, Elaine; Mick, Eric et al. (2014) Interleukin 1 receptor 1 and interleukin 1? regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol 34:552-64
Clancy, Lauren; Freedman, Jane E (2014) New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. J Thromb Thrombolysis 37:12-6
Freedman, Jane E (2014) Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease. Circ Res 114:1372-3
He, Xianbao; Berland, Robert; Mekasha, Samrawit et al. (2013) The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS Pathog 9:e1003569
Freedman, Jane E; Tanriverdi, Kahraman (2013) Defining miRNA targets: balancing simplicity with complexity. Circulation 127:2075-7
Shaik-Dasthagirisaheb, Y B; Huang, N; Baer, M T et al. (2013) Role of MyD88-dependent and MyD88-independent signaling in Porphyromonas gingivalis-elicited macrophage foam cell formation. Mol Oral Microbiol 28:28-39

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