The design, conduct and analysis of the studies to be conducted under the auspices of the Projects of this Program will benefit from expertise in biostatistics and epidemiology. The primary mission of the Biostatistics/Epidemiology Core (Core D) will be to assure the validity of study findings by providing comprehensive statistical, epidemiologic, and data management support.
The specific aims of this Core are: 1) to establish methods that promote adherence to standard protocols with particular attention to data collection and management;and 2) to collaborate with Project investigators in designing studies and analyzing data. Serving for the past 11 years as the WIHS Data Management and Analysis Center (WDMAC), Core D investigators have extensive experience with study design and analysis, collaborative research, and the study of HIV infection in women. Specifically, we have been at the forefront of leading and supporting HIV epidemiologic research studies. In addition, we have experience both with other program projects, and other studies of HIV pathogenesis. Our collective experience provides a strong framework to support the multifaceted data demands of this program project. Core D will provide data management and analytical support to each of the four Projects. In collaboration with Clinical Core investigators, we will provide epidemiologic and statistical expertise in identifying the characteristics and numbers of individuals for evaluation. The Core will work closely with the Tissue Culture and Virology Laboratory Core in establishing protocols for optimal data management and quality assurance. The Core will assist the Administrative Core in its oversight function by reporting on quality assurance and progress in statistical analysis. We will work with the Clinical and Administrative Cores on data collection, storage and transfer, providing optimum security of data and ease of use by investigators. These collaborations are aided by the history of collegial, productive working relationships between Core D leaders and Project/Core leaders. Dr. Elizabeth Golub will act as the Core Director and Dr. Stephen Gange as the Co-Director. The activities of the Core will occur in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Heath.

Public Health Relevance

The Biostatistics/Epidemiology Core will provide guidance and expertise that will enable the appropriate analysis of data collected by the four projects. By this contribution to the interpretation of the data, Core D will engage in the broader understanding of HIV pathogenesis and support the ability of these projects to make important contributions to science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI082971-05
Application #
8528320
Study Section
Special Emphasis Panel (ZAI1-TP-A)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$124,571
Indirect Cost
$22,921
Name
Rush University Medical Center
Department
Type
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Archary, Derseree; Liebenberg, Lenine J; Werner, Lise et al. (2015) Randomized Cross-Sectional Study to Compare HIV-1 Specific Antibody and Cytokine Concentrations in Female Genital Secretions Obtained by Menstrual Cup and Cervicovaginal Lavage. PLoS One 10:e0131906
Arslan, Sevim Yildiz; Yu, Yanni; Burdette, Joanne E et al. (2015) Novel three dimensional human endocervix cultures respond to 28-day hormone treatment. Endocrinology 156:1602-9
Tjernlund, Annelie; Carias, Ann M; Andersson, Sonia et al. (2015) Progesterone-based intrauterine device use is associated with a thinner apical layer of the human ectocervical epithelium and a lower ZO-1 mRNA expression. Biol Reprod 92:68
Aziz, Mariam; Mahmood, Fareeha; Mata, Mariana et al. (2015) Development of IgG Mediated Antibody Dependent Cell-mediated Cytotoxicity (ADCC) in the Serum and Genital Mucosa of HIV Seroconverters. J AIDS Clin Res 6:
Mirmonsef, Paria; Modur, Sharada; Burgad, Derick et al. (2015) Exploratory comparison of vaginal glycogen and Lactobacillus levels in premenopausal and postmenopausal women. Menopause 22:702-9
Jarrett, Olamide D; Brady, Kirsten E; Modur, Sharada P et al. (2015) T. vaginalis Infection Is Associated with Increased IL-8 and TNFr1 Levels but with the Absence of CD38 and HLADR Activation in the Cervix of ESN. PLoS One 10:e0130146
Spear, Greg T; McKenna, Mary; Landay, Alan L et al. (2015) Effect of pH on Cleavage of Glycogen by Vaginal Enzymes. PLoS One 10:e0132646
Allen, Shannon A; Carias, Ann M; Anderson, Meegan R et al. (2015) Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues. J Virol 89:5569-80
Mirmonsef, Paria; Hotton, Anna L; Gilbert, Douglas et al. (2014) Free glycogen in vaginal fluids is associated with Lactobacillus colonization and low vaginal pH. PLoS One 9:e102467
Aljawai, Yosra; Richards, Maureen H; Seaton, Melanie S et al. (2014) β-Catenin/TCF-4 signaling regulates susceptibility of macrophages and resistance of monocytes to HIV-1 productive infection. Curr HIV Res 12:164-73

Showing the most recent 10 out of 35 publications