The purpose of the Administrative Core (Core A) is to provide administrative support to the Program Director, to the Project Leaders of the individual projects, and to the scientific personnel of the Projects and Cores. Core A will provide a key administrative and organizational role that will enable the Project Leaders, their staff and the scientific cores to focus on their experimental and scientific efforts. The specific tasks of Core A will be to: a) facilitate interactions between Program investigators. Scientific Advisors/Consultants and administrative personnel;b) to plan and coordinate the meetings between the Project Leaders and their staff;c) to plan and coordinate the internal scientific advisory committee interactions with the Project Leaders and their staff;d) to plan and coordinate travel for the external scientific advisory committee members, the Project Leaders and their professional staff;e) to assist in assembling and maintaining the timely submission of multi-user and individual lACUC protocols that cover the efforts included within this program;f) to facilitate resource sharing between the Project Leaders;and g) to assist the Project Leaders in preparation of progress reports, financial reports and manuscripts for publication.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI087586-04
Application #
8470538
Study Section
Special Emphasis Panel (ZAI1-PTM-I)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
4
Fiscal Year
2013
Total Cost
$65,740
Indirect Cost
$23,867
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Yagisawa, Takafumi; Tanaka, Toshiaki; Miyairi, Satoshi et al. (2018) In the absence of natural killer cell activation donor-specific antibody mediates chronic, but not acute, kidney allograft rejection. Kidney Int :
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Tsuda, Hidetoshi; Su, Charles A; Tanaka, Toshiaki et al. (2018) Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells. JCI Insight 3:
Ayasoufi, Katayoun; Kohei, Naoki; Nicosia, Michael et al. (2018) Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia. Am J Transplant 18:1238-1246
Danturti, Sreedevi; Keslar, Karen S; Steinhoff, Leah R et al. (2017) CD4+ T lymphocytes produce adiponectin in response to transplants. JCI Insight 2:
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Benichou, Gilles; Gonzalez, Bruno; Marino, Jose et al. (2017) Role of Memory T Cells in Allograft Rejection and Tolerance. Front Immunol 8:170
Iida, Shoichi; Tsuda, Hidetoshi; Tanaka, Toshiaki et al. (2016) IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Reactive CD8 T Cell Responses to Cardiac Allografts. J Immunol 196:2827-37
Gorbacheva, Victoria; Fan, Ran; Fairchild, Robert L et al. (2016) Memory CD4 T Cells Induce Antibody-Mediated Rejection of Renal Allografts. J Am Soc Nephrol 27:3299-3307
Kohei, Naoki; Tanaka, Toshiaki; Tanabe, Kazunari et al. (2016) Natural killer cells play a critical role in mediating inflammation and graft failure during antibody-mediated rejection of kidney allografts. Kidney Int 89:1293-306

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