The Histopathology Core will provide integral support for all 3 projects. This core will centralize the pathology resources for all of the projects of the PPG. This will result in cost savings, increased quality control and maximal comparability between the results of the projects. Key functions of the Core include: 1) expert advise in immunohistological aspects of experimental design to optimize results;2) uniform tissue processing;3) tissue sectioning (frozen sections and paraffin-embedded sections);4) histochemical and immunohistochemical staining of tissue sections;5) pathological interpretation of tissue sections;6) documentation of the pathology by high quality digital microscopic photography;7) preparation of figures for manuscripts;8) storage and retrieval of stained slides for each of the projects. In addition, this Core will be responsible for ordering, quality assurance and control studies of all antibodies and reagents for use in the pathology methods. New reagents will be developed and evaluated as requested by investigators in the 3 projects.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PTM-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cleveland Clinic Lerner
United States
Zip Code
Gorbacheva, V; Ayasoufi, K; Fan, R et al. (2015) B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells. Am J Transplant 15:346-57
Gorbacheva, Victoria; Fan, Ran; Wang, Xi et al. (2015) IFN-? production by memory helper T cells is required for CD40-independent alloantibody responses. J Immunol 194:1347-56
Ishii, Daisuke; Rosenblum, Joshua M; Nozaki, Taiji et al. (2014) Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts. J Immunol 193:3816-24
Abe, T; Su, C A; Iida, S et al. (2014) Graft-derived CCL2 increases graft injury during antibody-mediated rejection of cardiac allografts. Am J Transplant 14:1753-64
Gaughan, A; Wang, J; Pelletier, R P et al. (2014) Key role for CD4 T cells during mixed antibody-mediated rejection of renal allografts. Am J Transplant 14:284-94
Su, C A; Iida, S; Abe, T et al. (2014) Endogenous memory CD8 T cells directly mediate cardiac allograft rejection. Am J Transplant 14:568-79
Baldwin 3rd, William M; Su, Charles A; Shroka, Thomas M et al. (2014) Experimental models of cardiac transplantation: design determines relevance. Curr Opin Organ Transplant 19:525-30
Basu, Abhijit; Poddar, Darshana; Robinet, Peggy et al. (2014) Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation. Arterioscler Thromb Vasc Biol 34:533-42
Liu, Qiang; Nassar, Ahmed; Farias, Kevin et al. (2014) Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers. Liver Transpl 20:987-99
Su, Charles A; Fairchild, Robert L (2014) Memory T Cells in Transplantation. Curr Transplant Rep 1:137-146

Showing the most recent 10 out of 18 publications