The Administrative Core provides the leadership, organizational structure, and planning that will allow HIVRAD team members to achieve their scientific goals through innovative, multidisciplinary research collaborations. The Administrative Core will serve as the coordinating center for this HIVRAD application and will be responsible for maintaining scientific and managerial oversight over all projects and cores. Most importantly, the Administrative Core will ensure that the scientific projects and cores make steady progress toward meeting project objectives and milestones. This administrative unit will also arrange meetings of the External Advisory Committee, make travel arrangements for HIVRAD team members to offsite NIAID-sponsored meetings and programs, organize internal scientific conferences, provide fiscal management, and prepare periodic progress reports and manuscripts.
The Specific Aims of the Administrative Core include: 1. To provide scientific leadership and governance that supports and unites the HIVRAD team. The Administrative Core will serve as the command and control center of the HIVRAD application. The core will establish an Executive Committee that will serve as the governing body of the grant. 2. To frequently review milestones and timelines and to ensure steady progress. The Executive Committee will conduct regular monitoring and evaluations to ensure that all milestones and research goals are met. The Executive Committee will also solve unforeseen problems as they arise by consulting with the External Advisors and seeking advice from outside experts. 3. To recruit and coordinate the HIVRAD Scientific Advisory Board. Members of the Scientific Advisory Board (SAB) will be selected based on their expertise in basic SIV/HIV biology, primate models and vaccine development. The SAB will review the Program on a yearly basis, providing a written report to the Principal Investigator and NIH program officials. 4. To provide financial management for the HIVRAD grant. The Core will manage HIVRAD resources in an efficient, effective, and transparent fashion through provision of sound fiscal management and ensuring efficient collaboration between investigators at UAB, Pittsburg and NCI-Frederick.

Public Health Relevance

The Administrative Core provides the leadership, organizational structure and planning, and will facilitate innovative, multidisciplinary research collaborations which are at the heart of the HIVRAD Mission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI088564-06
Application #
8861415
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
Li, Hui; Wang, Shuyi; Kong, Rui et al. (2016) Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A 113:E3413-22
Mason, Rosemarie D; Welles, Hugh C; Adams, Cameron et al. (2016) Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. PLoS Pathog 12:e1005537
Raehtz, Kevin; Pandrea, Ivona; Apetrei, Cristian (2016) The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression. Infect Genet Evol :
Pandrea, Ivona; Xu, Cuiling; Stock, Jennifer L et al. (2016) Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques. PLoS Pathog 12:e1005384
Bailey, Adam L; Lauck, Michael; Sibley, Samuel D et al. (2015) Zoonotic Potential of Simian Arteriviruses. J Virol 90:630-5
Policicchio, Benjamin B; Pandrea, Ivona; Apetrei, Cristian (2015) Population Bottlenecks and Pathogen Extinction: ""Make This Everyone's Mission to Mars, Including Yours"". J Virol 89:8104-6
Ma, Dongzhu; Xu, Cuiling; Cillo, Anthony R et al. (2015) Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research. J Virol 89:6155-60
Barbian, Hannah J; Decker, Julie M; Bibollet-Ruche, Frederic et al. (2015) Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas. MBio 6:
Langer, Simon M; Hopfensperger, Kristina; Iyer, Shilpa S et al. (2015) A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1. PLoS One 10:e0142118
Ma, Dongzhu; Jasinska, Anna J; Feyertag, Felix et al. (2014) Factors associated with siman immunodeficiency virus transmission in a natural African nonhuman primate host in the wild. J Virol 88:5687-705

Showing the most recent 10 out of 21 publications