The Administrative Core provides the leadership, organizational structure, and planning that will allow HIVRAD team members to achieve their scientific goals through innovative, multidisciplinary research collaborations. The Administrative Core will serve as the coordinating center for this HIVRAD application and will be responsible for maintaining scientific and managerial oversight over all projects and cores. Most importantly, the Administrative Core will ensure that the scientific projects and cores make steady progress toward meeting project objectives and milestones. This administrative unit will also arrange meetings of the External Advisory Committee, make travel arrangements for HIVRAD team members to offsite NIAID-sponsored meetings and programs, organize internal scientific conferences, provide fiscal management, and prepare periodic progress reports and manuscripts.
The Specific Aims of the Administrative Core include: 1. To provide scientific leadership and governance that supports and unites the HIVRAD team. The Administrative Core will serve as the command and control center of the HIVRAD application. The core will establish an Executive Committee that will serve as the governing body of the grant. 2. To frequently review milestones and timelines and to ensure steady progress. The Executive Committee will conduct regular monitoring and evaluations to ensure that all milestones and research goals are met. The Executive Committee will also solve unforeseen problems as they arise by consulting with the External Advisors and seeking advice from outside experts. 3. To recruit and coordinate the HIVRAD Scientific Advisory Board. Members of the Scientific Advisory Board (SAB) will be selected based on their expertise in basic SIV/HIV biology, primate models and vaccine development. The SAB will review the Program on a yearly basis, providing a written report to the Principal Investigator and NIH program officials. 4. To provide financial management for the HIVRAD grant. The Core will manage HIVRAD resources in an efficient, effective, and transparent fashion through provision of sound fiscal management and ensuring efficient collaboration between investigators at UAB, Pittsburg and NCI-Frederick.

Public Health Relevance

The Administrative Core provides the leadership, organizational structure and planning, and will facilitate innovative, multidisciplinary research collaborations which are at the heart of the HIVRAD Mission.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01AI088564-06
Application #
8861415
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
Smedley, Jeremy; Turkbey, Baris; Bernardo, Marcelino L et al. (2014) Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission. PLoS One 9:e92830
Ma, Dongzhu; Jasinska, Anna J; Feyertag, Felix et al. (2014) Factors associated with siman immunodeficiency virus transmission in a natural African nonhuman primate host in the wild. J Virol 88:5687-705
Roederer, Mario; Keele, Brandon F; Schmidt, Stephen D et al. (2014) Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature 505:502-8
Ma, Dongzhu; Jasinska, Anna; Kristoff, Jan et al. (2013) SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations. PLoS Pathog 9:e1003011
Lopker, Michael; Easlick, Juliet; Sterrett, Sarah et al. (2013) Heterogeneity in neutralization sensitivities of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol 87:5477-92
Parrish, Nicholas F; Gao, Feng; Li, Hui et al. (2013) Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci U S A 110:6626-33
Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing et al. (2013) Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 496:469-76
Liao, Hua-Xin; Tsao, Chun-Yen; Alam, S Munir et al. (2013) Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. J Virol 87:4185-201
Vaccari, Monica; Keele, Brandon F; Bosinger, Steven E et al. (2013) Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure. J Virol 87:3538-48
Kong, Rui; Li, Hui; Bibollet-Ruche, Frederic et al. (2012) Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection. J Virol 86:947-60

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