Core D will provide the informatics, computational biology, and statistical support for the analysis of antibody somatic genetics and the correlation of antibody genetics with affinity, neutralization capacity, and other correlates of protection. Core D personnel have developed state-of-the-art tools that permit such analyses to be conducted, and will apply these tools to the data generated by the investigators in the P01 research teams. Furthermore, Core D researchers will continue to develop methods as needed by the group as a whole.

Public Health Relevance

Affinity maturation is a key component of the immune response to vaccines. Antibodies become the first line of defense in post-vaccine exposure to the targeted pathogen through affinity maturation. Sophisticated mathematical analysis applied to technologically advanced data assays will enhance our understanding of this important process and greatly facilitate the design of greatly improved next-generation vaccines.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI089618-03
Application #
8717175
Study Section
Special Emphasis Panel (ZAI1-LR-I (M1))
Project Start
2013-08-01
Project End
2016-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$24,844
Indirect Cost
$3,221
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Jackson, Katherine J L; Liu, Yi; Roskin, Krishna M et al. (2014) Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host Microbe 16:105-14
Schmidt, Aaron G; Xu, Huafeng; Khan, Amir R et al. (2013) Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A 110:264-9