An administrative core (Core A) is requested in this proposal to facilitate institutional and investigator interactions at three universities (MIT, UCB, UCSF) and involving five investigators (Drs. Chakraborty, Groves, Kuriyan, Roose and Weiss). The budgets, fund distribution, reconciliation, and progress report preparation will be coordinated at UCSF where Dr. Weiss is located with the assistance of a research analyst. Such efforts will take time and demand a great deal of additional coordination and effort. A part-time effort (25% or 3 calendar months) of an administrative assistant will help facilitate communication between investigators, postdoctoral fellows, students and staff. This will include but not be limited to scheduling regular SKYPE video meetings and conference calls, distributing data and research communications, maintaining a web site, and setting up onsite meetings (at UCSF or UCB). We anticipate that Dr. Chakraborty and his team will travel to the Bay area twice a year for meetings of all investigators and their groups.

Public Health Relevance

Due to the complexity of the program project, involving 5 investigators and 3 institutions, it is necessary to ensure proper funds flow, distribution and reporting. In addition, facilitating communication across large distances needs to be facilitated and coordinated. The administrative core A will provide this coordination and improve efficiencies of these processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI091580-04
Application #
8875380
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Courtney, Adam H; Lo, Wan-Lin; Weiss, Arthur (2018) TCR Signaling: Mechanisms of Initiation and Propagation. Trends Biochem Sci 43:108-123
Shah, Neel H; Löbel, Mark; Weiss, Arthur et al. (2018) Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Elife 7:
Cantor, Aaron J; Shah, Neel H; Kuriyan, John (2018) Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites. Proc Natl Acad Sci U S A 115:E7303-E7312
Lo, Wan-Lin; Shah, Neel H; Ahsan, Nagib et al. (2018) Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol 19:733-741
Bandaru, Pradeep; Shah, Neel H; Bhattacharyya, Moitrayee et al. (2017) Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife 6:
Huang, William Y C; Ditlev, Jonathon A; Chiang, Han-Kuei et al. (2017) Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation. J Am Chem Soc 139:18009-18015
Visperas, Patrick R; Wilson, Christopher G; Winger, Jonathan A et al. (2017) Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov 22:324-331
Hsu, Lih-Yun; Cheng, Debra A; Chen, Yiling et al. (2017) Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. J Exp Med 214:833-849
Myers, Darienne R; Lau, Tannia; Markegard, Evan et al. (2017) Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep 19:1558-1571
Myers, Darienne R; Zikherman, Julie; Roose, Jeroen P (2017) Tonic Signals: Why Do Lymphocytes Bother? Trends Immunol 38:844-857

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