An administrative core (Core A) is requested in this proposal to facilitate institutional and investigator interactions at three universities (MIT, UCB, UCSF) and involving five investigators (Drs. Chakraborty, Groves, Kuriyan, Roose and Weiss). The budgets, fund distribution, reconciliation, and progress report preparation will be coordinated at UCSF where Dr. Weiss is located with the assistance of a research analyst. Such efforts will take time and demand a great deal of additional coordination and effort. A part-time effort (25% or 3 calendar months) of an administrative assistant will help facilitate communication between investigators, postdoctoral fellows, students and staff. This will include but not be limited to scheduling regular SKYPE video meetings and conference calls, distributing data and research communications, maintaining a web site, and setting up onsite meetings (at UCSF or UCB). We anticipate that Dr. Chakraborty and his team will travel to the Bay area twice a year for meetings of all investigators and their groups.
Due to the complexity of the program project, involving 5 investigators and 3 institutions, it is necessary to ensure proper funds flow, distribution and reporting. In addition, facilitating communication across large distances needs to be facilitated and coordinated. The administrative core A will provide this coordination and improve efficiencies of these processes.
|Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen et al. (2014) Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science 345:50-4|
|Tan, Ying Xim; Manz, Boryana N; Freedman, Tanya S et al. (2014) Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol 15:186-94|
|Au-Yeung, Byron B; Zikherman, Julie; Mueller, James L et al. (2014) A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A 111:E3679-88|
|Avalos, Ana M; Bilate, Angelina M; Witte, Martin D et al. (2014) Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. J Exp Med 211:365-79|
|Au-Yeung, Byron B; Melichar, Heather J; Ross, Jenny O et al. (2014) Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol 15:687-94|
|Jenkins, Misty R; Stinchcombe, Jane C; Au-Yeung, Byron B et al. (2014) Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife 3:e01310|
|Shekhar, Karthik; Brodin, Petter; Davis, Mark M et al. (2014) Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE). Proc Natl Acad Sci U S A 111:202-7|
|Ross, Jenny O; Melichar, Heather J; Au-Yeung, Byron B et al. (2014) Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A 111:E2550-8|
|Chakraborty, Arup K; Weiss, Arthur (2014) Insights into the initiation of TCR signaling. Nat Immunol 15:798-807|
|Lin, Wan-Chen; Iversen, Lars; Tu, Hsiung-Lin et al. (2014) H-Ras forms dimers on membrane surfaces via a protein-protein interface. Proc Natl Acad Sci U S A 111:2996-3001|
Showing the most recent 10 out of 17 publications