Abstract

The administrative core will be led by the PI, Peter Palese, with partial support by an experienced administrator, Nina Umerah, who will have space in the departmental office of the Department of Microbiology at the Mount Sinai School of Medicine. The core will facilitate communication among the participants of the P01 and will be responsible for obtaining permits required by regulatory bodies both inside and outside of the institution. The core will also be responsible for coordinating technology transfer issues arising from the work done with the support of the P01, organizing interactions of the Pis with the External Advisory Board, and building a website. Ms. Umerah is highly skilled in IT and thus will be a great help in allowing a smooth operation of this program.

Public Health Relevance

This program is aimed at developing novel broadly protective influenza virus vaccines which may result in improved and longer lasting influenza vaccine approaches.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI097092-02
Application #
8528834
Study Section
Special Emphasis Panel (ZAI1-RB-M)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$83,929
Indirect Cost
$19,319

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Fulton, Benjamin O; Sun, Weina; Heaton, Nicholas S et al. (2018) The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus. J Virol 92:
Coughlan, Lynda; Palese, Peter (2018) Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine. Cell Host Microbe 24:18-24
Henry, Carole; Palm, Anna-Karin E; Krammer, Florian et al. (2018) From Original Antigenic Sin to the Universal Influenza Virus Vaccine. Trends Immunol 39:70-79
Broecker, Felix; Liu, Sean T H; Sun, Weina et al. (2018) Immunodominance of Antigenic Site B in the Hemagglutinin of the Current H3N2 Influenza Virus in Humans and Mice. J Virol 92:
Bailey, Mark J; Broecker, Felix; Leon, Paul E et al. (2018) A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies. J Vis Exp :
Stamper, Christopher T; Wilson, Patrick C (2018) What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection? Cold Spring Harb Perspect Biol 10:
Ajmani, Gaurav S; Suh, Helen H; Wroblewski, Kristen E et al. (2017) Smoking and olfactory dysfunction: A systematic literature review and meta-analysis. Laryngoscope 127:1753-1761
Leon, Paul E; Wohlbold, Teddy John; He, Wenqian et al. (2017) Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies. J Vis Exp :
He, Wenqian; Chen, Chi-Jene; Mullarkey, Caitlin E et al. (2017) Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nat Commun 8:846
Martín-Vicente, María; Medrano, Luz M; Resino, Salvador et al. (2017) TRIM25 in the Regulation of the Antiviral Innate Immunity. Front Immunol 8:1187

Showing the most recent 10 out of 86 publications