The purpose of the Administrafive Core (Core A) is to provide key administrative and organizational support that will enable the Project Leaders, their staff and the scientific cores to focus on their experimental and scientific efforts. The specific tasks of Core A will be to: a) facilitate interactions between Program investigators. Scientific Advisors/Consultants and administrative personnel;b) plan and coordinate the meetings between the Project Leaders and their staff;c) plan and coordinate the internal scientific advisory committee interactions with the Project Leaders and their staff;d) plan and coordinate travel for the external scientific advisory committee members, the Project Leaders and their professional staff;e) assist in assembling and maintaining the fimely submission of multi-user and individual Institufional Animal Care and Use Committee (lACUC) protocols that cover the efforts included within this program;f) facilitate resource sharing among the Project Leaders;and g) assist the Project Leaders in the preparafion of progress reports, financial reports and manuscripts for publicafion.

Public Health Relevance

(Relevance) The purpose of the Administrative Core (Core A) is to provide key administrative and organizational support to the Program Project. This will enable the Project Leaders, their staff and the scientific cores to focus on their research efforts to understand how to induce, monitor and maintain a state of robust transplantation tolerance.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-MFH-I)
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University of Chicago
United States
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Chong, Anita S (2016) From Pipe Dream to Donor-Specific PC Elimination: Novel Ways to Target Alloantibodies. Transplantation 100:2238-2239
Lei, Yuk Man; Chen, Luqiu; Wang, Ying et al. (2016) The composition of the microbiota modulates allograft rejection. J Clin Invest 126:2736-44
Alegre, Maria-Luisa; Lakkis, Fadi G; Morelli, Adrian E (2016) Antigen Presentation in Transplantation. Trends Immunol 37:831-843
Miller, Michelle L; Chen, Jianjun; Daniels, Melvin D et al. (2016) Adoptive transfer of tracer alloreactive CD4(+) TCR-transgenic T cells alters the endogenous immune response to an allograft. Am J Transplant :
Molinero, Luciana L; Yin, Dengping; Lei, Yuk Man et al. (2016) High-Fat Diet-Induced Obesity Enhances Allograft Rejection. Transplantation 100:1015-21
Yang, Jinghui; Chen, Jianjun; Young, James S et al. (2016) Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation. Transplantation 100:1683-91
Young, J S; Chen, J; Miller, M L et al. (2016) Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection. Am J Transplant 16:2312-23
Chen, Jianjun; Wang, Qiang; Yin, Dengping et al. (2015) Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients. J Immunol 195:4069-73
Bartman, Caroline; Chong, Anita S; Alegre, Maria-Luisa (2015) The influence of the microbiota on the immune response to transplantation. Curr Opin Organ Transplant 20:1-7
Geissler, Edward K; Tullius, Stefan G; Chong, Anita S (2015) Establishment of a global virtual laboratory for transplantation: a symposium report. Transplantation 99:381-4

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