The purpose of the Administrafive Core (Core A) is to provide key administrative and organizational support that will enable the Project Leaders, their staff and the scientific cores to focus on their experimental and scientific efforts. The specific tasks of Core A will be to: a) facilitate interactions between Program investigators. Scientific Advisors/Consultants and administrative personnel;b) plan and coordinate the meetings between the Project Leaders and their staff;c) plan and coordinate the internal scientific advisory committee interactions with the Project Leaders and their staff;d) plan and coordinate travel for the external scientific advisory committee members, the Project Leaders and their professional staff;e) assist in assembling and maintaining the fimely submission of multi-user and individual Institufional Animal Care and Use Committee (lACUC) protocols that cover the efforts included within this program;f) facilitate resource sharing among the Project Leaders;and g) assist the Project Leaders in the preparafion of progress reports, financial reports and manuscripts for publicafion.

Public Health Relevance

(Relevance) The purpose of the Administrative Core (Core A) is to provide key administrative and organizational support to the Program Project. This will enable the Project Leaders, their staff and the scientific cores to focus on their research efforts to understand how to induce, monitor and maintain a state of robust transplantation tolerance.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1)
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University of Chicago
United States
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Alegre, Maria-Luisa (2018) What's new in transplantation tolerance? Curr Opin Organ Transplant 23:63-65
Miller, Michelle L; McIntosh, Christine M; Williams, Jason B et al. (2018) Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance. Cell Rep 24:2112-2126
Chong, Anita S; Ansari, M Javeed (2018) Heterogeneity of memory B cells. Am J Transplant 18:779-784
Young, James S; Khiew, Stella H-W; Yang, Jinghui et al. (2017) Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice. Front Immunol 8:1169
Khiew, Stella H; Yang, Jinghui; Young, James S et al. (2017) CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight 2:
Young, James S; McIntosh, Christine; Alegre, Maria-Luisa et al. (2017) Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans. Transplantation 101:2671-2681
Young, J S; Daniels, M D; Miller, M L et al. (2017) Erosion of Transplantation Tolerance After Infection. Am J Transplant 17:81-90
Miller, Michelle L; Alegre, Maria-Luisa; Chong, Anita S (2017) Transplantation tolerance after allograft rejection. Curr Opin Organ Transplant 22:64-70
Chong, A S; Khiew, S H (2017) Transplantation tolerance: don't forget about the B cells. Clin Exp Immunol 189:171-180
Chong, Anita S (2017) Alone Again, Naturally: B Cells Encountering Antigen Without T cells. Transplantation 101:1956-1958

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