The administrative core will be responsible for all administration of this program. The program proposed here contains 3 independent yet linked projects and 2 scientific cores that will develop 3 different strategies to deliver non-coding RNAs capable of transcriptionally suppressing and directing the excising of HIV-1 or the CCRS chemokine co-receptor to either HIV-1 infected cells or those immune cells targeted for infection by HIV-1. The administrative core will function by: Overseeing the fiscal, administrative, and legal responsibilities for the entire program;fostering interactions between the different investigators and their respective projects;and assuming responsibility for confirming that all research is conducted in an optimal and ethical manner. As such the role of the administrative core is integral to the success of this program.
The specific aims of the administrative core are: (1) Coordinate administrative and fiscal requirements of the program. (2) Supervise and foster the scientific progress of the program. (3) Oversee the dissemination and sharing of the results from each project within the program.

Public Health Relevance

The administrative core will oversee the fiscal, administrative, and legal responsibilities for the entire program with the aim of fostering interactions between the different investigators and their respective projects and assuring that all research is conducted in an optimal and ethical manner.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI099783-02
Application #
8451990
Study Section
Special Emphasis Panel (ZAI1-RB-A)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
2
Fiscal Year
2013
Total Cost
$128,508
Indirect Cost
$36,295
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Zhou, Jiehua; Satheesan, Sangeetha; Li, Haitang et al. (2015) Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity. Chem Biol 22:379-90
Vadie, Nadia; Saayman, Sheena; Lenox, Alexandra et al. (2015) MYCNOS functions as an antisense RNA regulating MYCN. RNA Biol 12:893-9

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