The HIVRAD Program described in this application consists of scientists from several disciplines located in a wide geographical area, stretching from the West Coast of the US to the West Coast of Africa (Cameroon). This Core is designed to facilitate communication among the scientists, the institutions, and among the Pis of each Project, the Cores, and the co-investigators and consultants. In addition, it will facilitate communication between Pis of this and other HIVRADs as well as the DAIDS staff and the Scientific Advisory Board (SAB) of this HIVRAD. Therefore, Core A provides services to all Projects and Scientific Cores. Core A is structured around three Specific Aims:
Aim 1. To promote open discussion and communication among members, facilitate sharing of scientific data and resources, and enable periodic strategic planning. To accomplish this, the administrative staff will organize and coordinate a) monthly teleconferences of the Executive Committee, b) monthly Work-in-Progress videoteleconferences in which, during each session, the leader or a member of a different Project or Core will present an update of on-going work, c) bi-annual meetings of all HIVRAD participants, and d) annual meetings of the SAB to be held in conjunction with the DAIDS site visit.
Aim 2. To maintain the password-protected SharePoint web portal we have established (http://sp.nvumc.org/nvuhiv/default.aspx) which includes blogs for each Project (to promote free and open communication among members), data libraries for each Project and Core (to afford easy browsing and searching of all data), Powerpoint presentations, progress reports, manuscripts (in preparation and in press), and inventories of reagents (monoclonal Abs, protein immunogens, DNA vaccines, viruses, etc.). This portal will be password-protected and accessible via internet from any computer in the world.
And Aim 3. To regularly monitor the performance of all scientific projects and to track the expenditures for each Project and Core. This Core will evaluate and report on progress to the SAB and the DAIDS staff, as well as monitor the implementation of changes recommended by the SAB and DAIDS.

Public Health Relevance

Efficient management is essential for the efficient functioning of a multi-institutional program. Through its activities, this Core will facilitate the achievement of the goals of each of the Projects and Cores, and of the Program as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI100151-02
Application #
8531148
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
2018-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$144,163
Indirect Cost
$44,653
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Zolla-Pazner, Susan (2014) A critical question for HIV vaccine development: which antibodies to induce? Science 345:167-8
Zolla-Pazner, Susan; deCamp, Allan; Gilbert, Peter B et al. (2014) Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. PLoS One 9:e87572
Evering, Teresa H; Kamau, Edwin; St Bernard, Leslie et al. (2014) Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope. Retrovirology 11:65
Dutta, Moumita; Liu, Jun; Roux, Kenneth H et al. (2014) Visualization of retroviral envelope spikes in complex with the V3 loop antibody 447-52D on intact viruses by cryo-electron tomography. J Virol 88:12265-75
Spurrier, Brett; Sampson, Jared; Gorny, Miroslaw K et al. (2014) Functional implications of the binding mode of a human conformation-dependent V2 monoclonal antibody against HIV. J Virol 88:4100-12
Upadhyay, Chitra; Mayr, Luzia M; Zhang, Jing et al. (2014) Distinct mechanisms regulate exposure of neutralizing epitopes in the V2 and V3 loops of HIV-1 envelope. J Virol 88:12853-65
Mayr, Luzia M; Cohen, Sandra; Spurrier, Brett et al. (2013) Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2. PLoS One 8:e70859
Pan, Ruimin; Sampson, Jared M; Chen, Yuxin et al. (2013) Rabbit anti-HIV-1 monoclonal antibodies raised by immunization can mimic the antigen-binding modes of antibodies derived from HIV-1-infected humans. J Virol 87:10221-31