Histology - Core D Mice surviving sepsis display prolonged inflammation in the brain. The Histology Core will provide high quality immunohistochemistry and in situ hybridization of brain tissue to assess brain inflammation and histologic correlates of impaired behavior or cognition. The availability of a Core for these procedures will ensure comparability across all projects and will be cost saving.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI102852-01A1
Application #
8667809
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Feinstein Institute for Medical Research
Department
Type
DUNS #
City
Manhasset
State
NY
Country
United States
Zip Code
11030
Zaghloul, Nahla; Addorisio, Meghan E; Silverman, Harold A et al. (2017) Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors. Front Immunol 8:1673
Huerta, Patricio T; Robbiati, Sergio; Huerta, Tomás Salvador et al. (2016) Preclinical models of overwhelming sepsis implicate the neural system that encodes contextual fear memory. Mol Med 22:
Olofsson, Peder S; Steinberg, Benjamin E; Sobbi, Roozbeh et al. (2016) Blood pressure regulation by CD4(+) lymphocytes expressing choline acetyltransferase. Nat Biotechnol 34:1066-1071
Vingtdeux, Valérie; Chang, Eric H; Frattini, Stephen A et al. (2016) CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Sci Rep 6:24250
Honig, Gerard; Mader, Simone; Chen, Huiyi et al. (2016) Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve. PLoS One 11:e0144215
Brimberg, L; Mader, S; Jeganathan, V et al. (2016) Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice. Mol Psychiatry 21:1663-1671
Valdés-Ferrer, Sergio I; Papoin, Julien; Dancho, Meghan E et al. (2015) HMGB1 mediates anemia of inflammation in murine sepsis survivors. Mol Med :
Volpe, Bruce T; Berlin, Rose Ann; Frankfurt, Maya (2015) The brain at risk: the sepsis syndrome and lessons from preclinical experiments. Immunol Res 63:70-4
Chang, Eric H; Volpe, Bruce T; Mackay, Meggan et al. (2015) Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor. EBioMedicine 2:755-64
Brimberg, Lior; Mader, Simone; Fujieda, Yuichiro et al. (2015) Antibodies as Mediators of Brain Pathology. Trends Immunol 36:709-724

Showing the most recent 10 out of 12 publications