Abstract

The overall objective of the Administrative Core is to coordinate and integrate all activities of the Program Project, provide administrative support, and facilitate the interactions and communication between Program members to ensure that the scientific goals are achieved in the most efficient manner. In particular, the Core will: (1) Manage all administrative functions of the Program Project;(2) Organize monthly meetings to discuss research progress;(3) Oversee financial aspects of the Program Project;(4) Organize annual mini-symposia of the Program research staff and meetings of the External Advisory Board;(5) Interact with institutional Research Compliance Offices and NIH staff with regard to regulatory issues;(6) Provide administrative support to Program participants in data management and preparation of materials for presentations and publications: (7) Coordinate and oversee timely submission of progress reports;(8) Maintain the database for the Cores and Projects;(9) Monitor the effectiveness of the Cores and Projects with regard to meeting the objectives and milestones.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI106705-01A1
Application #
8779077
Study Section
Special Emphasis Panel (ZAI1-RWM-M (S3))
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$80,978
Indirect Cost
$21,056

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Notari, Silvio; Appleby, Brian S; Gambetti, Pierluigi (2018) Variably protease-sensitive prionopathy. Handb Clin Neurol 153:175-190
Diaz-Espinoza, R; Morales, R; Concha-Marambio, L et al. (2018) Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo. Mol Psychiatry 23:777-788
Cali, Ignazio; Cohen, Mark L; Haik, Stephane et al. (2018) Iatrogenic Creutzfeldt-Jakob disease with Amyloid-? pathology: an international study. Acta Neuropathol Commun 6:5
Theint, Theint; Xia, Yongjie; Nadaud, Philippe S et al. (2018) Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy. J Am Chem Soc 140:13161-13166
Cracco, Laura; Appleby, Brian S; Gambetti, Pierluigi (2018) Fatal familial insomnia and sporadic fatal insomnia. Handb Clin Neurol 153:271-299
Li, Qiuye; Wang, Fei; Xiao, Xiangzhu et al. (2018) Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions. J Biol Chem 293:18494-18503
Aucoin, Darryl; Xia, Yongjie; Theint, Theint et al. (2018) Protein-solvent interfaces in human Y145Stop prion protein amyloid fibrils probed by paramagnetic solid-state NMR spectroscopy. J Struct Biol :
Shannon, Matthew D; Theint, Theint; Mukhopadhyay, Dwaipayan et al. (2018) Conformational Dynamics in the Core of Human Y145Stop Prion Protein Amyloid Probed by Relaxation Dispersion NMR. Chemphyschem :
Kim, Chae; Xiao, Xiangzhu; Chen, Shugui et al. (2018) Artificial strain of human prions created in vitro. Nat Commun 9:2166
Aguilar-Calvo, Patricia; Xiao, Xiangzhu; Bett, Cyrus et al. (2017) Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep 7:43295

Showing the most recent 10 out of 23 publications