We have noted that a third of 300 patients with melanomas have unusual nevi on their skin in contrast to four percent of normal controls. Only those patients with chronic indolent metastatic melanoma who survive for many years with overt or covert disease develop vitiligo. Melanocytotoxins like phenols, catechols, and hydroquinones have a unique proliferative and stimulating effect on Langerhans cells in the skin of mice. Contact allergens like DNFB and oxazolone do not produce these effects. PUVA, but not shortwave UV light, depletes murine skin of Ia positive dendritic cells, i.e., Langerhans cells. Similarly, cortisone, but not nitrogen mustard, depletes the skin of Langerhans cells.

Project Start
1979-04-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
Boissy, R E; Trinkle, L S; Nordlund, J J (1990) Neural-tube-derived melanocyte subsets undergo commitment to their distinct lineages in culture. Cell Differ Dev 30:129-45
Dunston, G M; Halder, R M (1990) Vitiligo is associated with HLA-DR4 in black patients. A preliminary report. Arch Dermatol 126:56-60
Boissy, R E; Trinkle, L S; Nordlund, J J (1989) Separation of pigmented and albino melanocytes and the concomitant evaluation of endogenous peroxide content using flow cytometry. Cytometry 10:779-87
Boissy, R E; Gecks, S; Smyth Jr, J R et al. (1988) Ocular pathology in the minimally depigmented subline of the vitiliginous Smyth chicken. Pigment Cell Res 1:303-14
Shiohara, T; Moellmann, G; Jacobson, K et al. (1987) Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer. J Immunol 138:1979-86
Shiohara, T; Ruddle, N H; Horowitz, M et al. (1987) Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. I. Destruction of B16 melanoma cells mediated by bystander cytolysis in vitro. J Immunol 138:1971-8
Boissy, R E; Moellmann, G E; Lerner, A B (1987) Morphology of melanocytes in hair bulbs and eyes of vitiligo mice. Am J Pathol 127:380-8
Lerner, A B; Halaban, R; Klaus, S N et al. (1987) Transplantation of human melanocytes. J Invest Dermatol 89:219-24
Boissy, R E; Moellmann, G; Trainer, A T et al. (1986) Delayed-amelanotic (DAM or Smyth) chicken: melanocyte dysfunction in vivo and in vitro. J Invest Dermatol 86:149-56
Lerner, A B; Shiohara, T; Boissy, R E et al. (1986) A mouse model for vitiligo. J Invest Dermatol 87:299-304