The proposed program project will develop cutaneous gene therapy for junctional epidermolysis bullosa (JEB) while studying key relevant features of cutaneous biology. The goals of this project focus on further characterizing basement membrane zone proteins in relationship to blistering human skin disease, as well as on cutaneous gene regulation strategies, stem cell biology and gene delivery methods. We shall attempt to develop effective approaches for long term delivery of therapeutic genes to the skin as a foundation for gene therapy for JEB and for systematic application in the treatment of human genetic skin disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR044012-03
Application #
6029988
Study Section
Special Emphasis Panel (ZAR1-TLB-B (M1))
Program Officer
Moshell, Alan N
Project Start
1997-09-30
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Stanford University
Department
Dermatology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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