This Core will provide advice, vectors, and as needed actual vector construction and validation for theproduction of needed knockin and BAC Tg mice. It will also provide initial validation and breeding of suchmice, and will transfer mice as needed to the individual projects. However, it will not generally be a mouse-breeding repository. Finally, the Core will provide access to and advice on mouse SNP genotyping which willallow the projects to appropriately conduct

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Program Projects (P01)
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Special Emphasis Panel (ZAR1-EHB-D)
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University of Massachusetts Medical School Worcester
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Ericson, Jeffrey A; Duffau, Pierre; Yasuda, Kei et al. (2014) Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways. PLoS One 9:e108553
Yasuda, Kei; Watkins, Amanda A; Kochar, Guneet S et al. (2014) Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One 9:e103478
Pelka, Karin; Phulphagar, Kshiti; Zimmermann, Jana et al. (2014) Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol 193:3257-61
Watkins, Amanda A; Bonegio, Ramon G B; Rifkin, Ian R (2014) Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. Methods Mol Biol 1169:143-58
Aprahamian, Tamar R; Bonegio, Ramon G; Weitzner, Zachary et al. (2014) Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology 142:363-73
Teichmann, Lino L; Schenten, Dominik; Medzhitov, Ruslan et al. (2013) Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity 38:528-40
Bossaller, Lukas; Rathinam, Vijay A K; Bonegio, Ramon et al. (2013) Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol 191:2104-14
Yasuda, Kei; Nundel, Kerstin; Watkins, Amanda A et al. (2013) Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol 25:295-306
Nickerson, Kevin M; Christensen, Sean R; Cullen, Jaime L et al. (2013) TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J Immunol 190:1447-56
Nickerson, Kevin M; Cullen, Jaime L; Kashgarian, Michael et al. (2013) Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1. J Immunol 190:3889-94

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