The overall Program Project grant will be administered through Brigham and Women's Hospital by means of the Administrative Core A. Project 1 will take place at Brigham and Women's Hospital, Project 2 at the School of Veterinary Medicine at the University of California at Davis via a subcontract with the Brigham and Women's Hospital, Project 3 at the University or Colorado Health Sciences center via a subcontract with the Brigham and Women's Hospital, Core B at Brigham and Women's Hospital, Core C at the University of Leeds via a subcontract with the Brigham and Women's Hospital and Core D at the University of Pennsylvania via a subcontract with the Brigham and Women's Hospital. As various facets of research administration differ among these institutions. Administrative Core A will play a critical role in coordinating the administration of the financial management of the overall effort and will facilitate the scientific investigations by scheduling and facilitating regular video-conference group laboratory meetings and other joint activities such as the bi-annual investigator meetings and annual review. The five groups of investigators are experienced in different but intellectually overlapping aspects of Malignant Hyperthermia and their collaboration will allow complementary approaches to understanding the mechanisms controlling the clinical MH syndrome. Collectively the projects and cores will achieve an integrated understanding of MH susceptibility that could not be accomplished individually by any of the individual groups working alone. The Administrative Core A will allow comprehensive ongoing coordination of the data, enhance communication between the research laboratories and facilitate control of the budget.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR052354-08
Application #
8667318
Study Section
Special Emphasis Panel (ZAR1-MLB)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
Fiscal Year
2014
Total Cost
$35,852
Indirect Cost
$8,301
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Franzini-Armstrong, Clara (2016) Can the Arrangement of RyR2 in Cardiac Muscle Be Predicted? Biophys J 110:2563-5
Polster, Alexander; Nelson, Benjamin R; Olson, Eric N et al. (2016) Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Proc Natl Acad Sci U S A 113:10986-91
Bannister, Roger A; Sheridan, David C; Beam, Kurt G (2016) Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1. Biophys J 110:912-21
Ronjat, Michel; Feng, Wei; Dardevet, Lucie et al. (2016) In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A 113:E2460-8
Perni, Stefano; Dynes, Joseph L; Yeromin, Andriy V et al. (2015) Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry. Proc Natl Acad Sci U S A 112:E5533-42
Franzini-Armstrong, Clara (2015) Electron Microscopy: From 2D to 3D Images with Special Reference to Muscle. Eur J Transl Myol 25:4836
Perni, Stefano; Marsden, Kurt C; Escobar, Matias et al. (2015) Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle. J Gen Physiol 145:253
Henríquez-Olguín, Carlos; Altamirano, Francisco; Valladares, Denisse et al. (2015) Altered ROS production, NF-κB activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells. Biochim Biophys Acta 1852:1410-9
Fiszer, Dorota; Shaw, Marie-Anne; Fisher, Nickla A et al. (2015) Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness. Anesthesiology 122:1033-46
Perni, Stefano; Marsden, Kurt C; Escobar, Matias et al. (2015) Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle. J Gen Physiol 145:173-84

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