The overall Program Project grant will be administered through Brigham and Women's Hospital by means of the Administrative Core A. Project 1 will take place at Brigham and Women's Hospital, Project 2 at the School of Veterinary Medicine at the University of California at Davis via a subcontract with the Brigham and Women's Hospital, Project 3 at the University or Colorado Health Sciences center via a subcontract with the Brigham and Women's Hospital, Core B at Brigham and Women's Hospital, Core C at the University of Leeds via a subcontract with the Brigham and Women's Hospital and Core D at the University of Pennsylvania via a subcontract with the Brigham and Women's Hospital. As various facets of research administration differ among these institutions. Administrative Core A will play a critical role in coordinating the administration of the financial management of the overall effort and will facilitate the scientific investigations by scheduling and facilitating regular video-conference group laboratory meetings and other joint activities such as the bi-annual investigator meetings and annual review. The five groups of investigators are experienced in different but intellectually overlapping aspects of Malignant Hyperthermia and their collaboration will allow complementary approaches to understanding the mechanisms controlling the clinical MH syndrome. Collectively the projects and cores will achieve an integrated understanding of MH susceptibility that could not be accomplished individually by any of the individual groups working alone. The Administrative Core A will allow comprehensive ongoing coordination of the data, enhance communication between the research laboratories and facilitate control of the budget.
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