The overall Program Project grant will be administered through Brigham and Women's Hospital by means of the Administrative Core A. Project 1 will take place at Brigham and Women's Hospital, Project 2 at the School of Veterinary Medicine at the University of California at Davis via a subcontract with the Brigham and Women's Hospital, Project 3 at the University or Colorado Health Sciences center via a subcontract with the Brigham and Women's Hospital, Core B at Brigham and Women's Hospital, Core C at the University of Leeds via a subcontract with the Brigham and Women's Hospital and Core D at the University of Pennsylvania via a subcontract with the Brigham and Women's Hospital. As various facets of research administration differ among these institutions. Administrative Core A will play a critical role in coordinating the administration of the financial management of the overall effort and will facilitate the scientific investigations by scheduling and facilitating regular video-conference group laboratory meetings and other joint activities such as the bi-annual investigator meetings and annual review. The five groups of investigators are experienced in different but intellectually overlapping aspects of Malignant Hyperthermia and their collaboration will allow complementary approaches to understanding the mechanisms controlling the clinical MH syndrome. Collectively the projects and cores will achieve an integrated understanding of MH susceptibility that could not be accomplished individually by any of the individual groups working alone. The Administrative Core A will allow comprehensive ongoing coordination of the data, enhance communication between the research laboratories and facilitate control of the budget.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-MLB)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
United States
Zip Code
Lavorato, Manuela; Iyer, V Ramesh; Dewight, Williams et al. (2017) Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges. Proc Natl Acad Sci U S A 114:E849-E858
Holland, Erika B; Goldstone, Jared V; Pessah, Isaac N et al. (2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquat Toxicol 192:105-115
Zhang, Rui; Pessah, Isaac N (2017) Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A. Mol Pharmacol 91:428-436
Perni, Stefano; Lavorato, Manuela; Beam, Kurt G (2017) De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release. Proc Natl Acad Sci U S A 114:13822-13827
Linsley, Jeremy W; Hsu, I-Uen; Groom, Linda et al. (2017) Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci U S A 114:E228-E236
Lavorato, Manuela; Gupta, Pawan K; Hopkins, Philip M et al. (2016) Skeletal Muscle Microalterations in Patients Carrying Malignant Hyperthermia-Related Mutations of the e-c Coupling Machinery. Eur J Transl Myol 26:6105
Ronjat, Michel; Feng, Wei; Dardevet, Lucie et al. (2016) In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A 113:E2460-8
Franzini-Armstrong, Clara (2016) Can the Arrangement of RyR2 in Cardiac Muscle Be Predicted? Biophys J 110:2563-5
Hopkins, Philip M; Fiszer, Dorota; Shaw, Marie-Anne et al. (2016) In Reply. Anesthesiology 124:511
Polster, Alexander; Nelson, Benjamin R; Olson, Eric N et al. (2016) Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation. Proc Natl Acad Sci U S A 113:10986-91

Showing the most recent 10 out of 73 publications