This Center consists of three highly coordinated projects, conducted on the identical participants (Ps) and supported by a Recruitment and Phenotyping Core. Pis have substantial neuroscientific expertise, enjoy historical and current research collaborations, and direct major laboratories with substantial infrastructure. These will be harnessed to make significant progress on a neuroscientific understanding of meditation by collecting measures allowing the synthesis of neuroimaging, behavioral (emotion regulation, stroop, breath counting, working memory, affective Go/No-go, attentional blink), immune (white blood cell counts and inflammatory cell differentials), autonomic nervous system functioning, sleep (PSG with high-density EEG, EMG, EOG, leg EMG, EKG, pulse oximetry, airflow, respiratory effort, position and video, dream reports, and Mismatch Negativity paradigm given during non-REM sleep), questionnaire (including mental health symptoms, compassion, mindfulness, medical symptoms, sustainable well-being, and ecological footprint), and interview data (interviews with study Ps' significant others will provide third-person reports on compassion and mindfulness). The Core will recruit, screen and schedule Ps for all three projects, including: (1) Long-term meditators (LTM; n=40); (2) Meditation naive Ps (MNP) diagnosed with asthma (MNP-A; n=80), a clinical sample with relevance for inflammatory processes as well as mental health risks; and (3) Meditation naive Ps without asthma (MNP-NA; n=120). After completion of T l measures, all MNPs will be randomized to either MBSR, HEP (an active comparison group that we pioneered), or a wait-list control group (WL). The WL group will serve as a control for MNPs in HEP and MBSR as well as LTMs. MNP-As will be randomized to either MBSR or WL. All Ps will be assessed on measures for all three projects at two time points, pre- (Tl) and post-intervention (T2) for MNPs with a third time point (T3) for LTMs and WL. Instead of being assigned an intervention, LTMs will be randomized to 3 days (23 hours total) of either mindfulness or loving-kindness-compassion practice at T2 (with the alternate practice type at T3).

Public Health Relevance

The Research Participation and Phenotyping Core will coordinate the scheduling and recruiting of participants for all three projects and synthesizes and disseminates data so that cross-project analyses can be conducted. In addition, measures of use in identifying individual differences applicable across all three projects are collected.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program Projects (P01)
Project #
5P01AT004952-08
Application #
8897276
Study Section
Special Emphasis Panel (ZAT1)
Project Start
Project End
2016-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Siclari, Francesca; Bernardi, Giulio; Cataldi, Jacinthe et al. (2018) Dreaming in NREM Sleep: A High-Density EEG Study of Slow Waves and Spindles. J Neurosci 38:9175-9185
Goldberg, Simon B; Tucker, Raymond P; Greene, Preston A et al. (2018) Mindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis. Clin Psychol Rev 59:52-60
Sanders, R D; Mostert, N; Lindroth, H et al. (2018) Is consciousness frontal? Two perioperative case reports that challenge that concept. Br J Anaesth 121:330-332
Dentico, Daniela; Bachhuber, David; Riedner, Brady A et al. (2018) Acute effects of meditation training on the waking and sleeping brain: Is it all about homeostasis? Eur J Neurosci 48:2310-2321
Baird, Benjamin; Castelnovo, Anna; Riedner, Brady A et al. (2018) Human Rapid Eye Movement Sleep Shows Local Increases in Low-Frequency Oscillations and Global Decreases in High-Frequency Oscillations Compared to Resting Wakefulness. eNeuro 5:
Weng, Helen Y; Lapate, Regina C; Stodola, Diane E et al. (2018) Visual Attention to Suffering After Compassion Training Is Associated With Decreased Amygdala Responses. Front Psychol 9:771
Sanders, R D; Banks, M I; Darracq, M et al. (2018) Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy. Br J Anaesth 121:1084-1096
Darracq, Matthieu; Funk, Chadd M; Polyakov, Daniel et al. (2018) Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia. Sci Rep 8:16664
Siclari, Francesca; Tononi, Giulio (2017) Local aspects of sleep and wakefulness. Curr Opin Neurobiol 44:222-227
Davidson, Richard J; Dahl, Cortland J (2017) Varieties of Contemplative Practice. JAMA Psychiatry 74:121-123

Showing the most recent 10 out of 65 publications