The Neuroimaging and Biostatistics (NIBS) Core, under the leadership of Dr. Bruce Rosen, will provide technical support to synthesize and integrate neuroimaging and statistical methods and analyses across the CERC Projects. Dr. Rosen, who is also the PI ofthe proposed CERC to investigate the central mechanisms of acupuncture action in chronic low back pain, is Director of the Athinoua A. Martinos Center for Biomedical Imaging at MGH. The Martinos Center has provided the broad research community with a range of innovations in the domains of MRI acquisition and analysis, many of which our group has extensive experience using to study acupuncture mechanisms in the brain. The three Projects in our proposed CERC focus on evaluating how different components of acupuncture therapy contribute to analgesia in chronic low back pain (cLBP). By providing a common image acquisition and analysis framework, the NIBS Core will facilitate the ability to perform intra- and inter-project analyses as well as larger-scale analyses that integrate not only across the CERC, but also across our other related NCCAM-funded studies, allowing us to address larger-scale questions about the neurobiology of acupuncture action in chronic pain conditions, and thus increase the value of such data to the broader community when shared according to our Data Sharing Plan. Specifically, the NIBS Core will seek to optimize and integrate neuroimaging methods across projects, which will be critical for cross-project synergy and pooled analysis. Further, the Core aims to provide unified, comprehensive data analysis and biostatistical support for all projects, as well as neuroanatomical support to ensure that our hypotheses and inferences gleaned from the neuroimaging data are firmly grounded in a consistent and up-to-date neuroanatomical framework. The NIBS core will also aim to organize a unified database and data sharing infrastructure for data collected across projects. Finally, this core will support and/or perform exploratory analyses on combined datasets collected from all three projects.

Public Health Relevance

The Neuroimaging and Biostatistics Core will support the CERC Projects by providing a unified framework for the neuroimaging analyses. This framework will improve cross-project synergy and ensure that the whole of our CERC PPG is greater than the sum of its parts.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program Projects (P01)
Project #
5P01AT006663-03
Application #
8496735
Study Section
Special Emphasis Panel (ZAT1-SM)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$182,667
Indirect Cost
$77,686
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Song, Wenwen; Dai, Minhui; Xuan, Lihua et al. (2017) Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy. Neural Plast 2017:8796239
Garcia, Ronald G; Lin, Richard L; Lee, Jeungchan et al. (2017) Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients. Pain 158:1461-1472
Ellingsen, D-M; Garcia, R G; Lee, J et al. (2017) Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: A cross-comparison with migraine and healthy adults. Neurogastroenterol Motil 29:
Wang, Zengjian; Wang, Xiaoyun; Liu, Jian et al. (2017) Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder. J Psychiatr Res 84:18-26
Egorova, N; Park, J; Kong, J (2017) In the face of pain: The choice of visual cues in pain conditioning matters. Eur J Pain 21:1243-1251
Fang, Jiliang; Egorova, Natalia; Rong, Peijing et al. (2017) Early cortical biomarkers of longitudinal transcutaneous vagus nerve stimulation treatment success in depression. Neuroimage Clin 14:105-111
Song, Wenwen; Cao, Zhijian; Lang, Courtney et al. (2017) Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. Neuroimage Clin 14:122-129
Lazaridou, Asimina; Kim, Jieun; Cahalan, Christine M et al. (2017) Effects of Cognitive-Behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia. Clin J Pain 33:215-221
Li, Zhengjie; Lan, Lei; Zeng, Fang et al. (2017) The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment. Cephalalgia 37:161-176
Song, Andrew H; Kucyi, Aaron; Napadow, Vitaly et al. (2017) Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci 37:6938-6945

Showing the most recent 10 out of 77 publications