Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA008341-20
Application #
4690179
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
Yang, J M; Sullivan, G F; Hait, W N (1997) Regulation of the function of P-glycoprotein by epidermal growth factor through phospholipase C. Biochem Pharmacol 53:1597-604
Yang, J M; Chin, K V; Hait, W N (1996) Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells. Cancer Res 56:3490-4
Buzaid, A C; Pizzorno, G; Marsh, J C et al. (1995) Biochemical modulation of 5-fluorouracil with brequinar: results of a phase I study. Cancer Chemother Pharmacol 36:373-8
Yang, J M; Chin, K V; Hait, W N (1995) Involvement of phospholipase C in heat-shock-induced phosphorylation of P-glycoprotein in multidrug resistant human breast cancer cells. Biochem Biophys Res Commun 210:21-30
Marsh, J C; Durivage, H J; Davis, C et al. (1992) Phase II study of pulse 5-fluoro-2'-deoxyuridine and leucovorin in advanced colorectal cancer patients previously treated with chemotherapy. Am J Clin Oncol 15:115-8
Aftab, D T; Ballas, L M; Loomis, C R et al. (1991) Structure-activity relationships of phenothiazines and related drugs for inhibition of protein kinase C. Mol Pharmacol 40:798-805
Murren, J R; Ganpule, S; Sarris, A et al. (1991) A phase II trial of cyclosporin A in the treatment of refractory metastatic colorectal cancer. Am J Clin Oncol 14:208-10
Murren, J R; Buzaid, A C; Hait, W N (1991) Critical analysis of neoadjuvant therapy for Stage IIIa non-small cell lung cancer [corrected] Am Rev Respir Dis 143:889-94
Hait, W N; Byrne, T N; Piepmeier, J et al. (1990) The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas. Cancer Res 50:6636-40
Kacinski, B M; Chambers, S K; Stanley, E R et al. (1990) The cytokine CSF-1 (M-CSF) expressed by endometrial carcinomas in vivo and in vitro, may also be a circulating tumor marker of neoplastic disease activity in endometrial carcinoma patients. Int J Radiat Oncol Biol Phys 19:619-26

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