Viruses cause approximately 15% of human cancers. A viral etiology to a human cancer can have substantive consequences on its treatment and prevention. For example, many virally-caused human cancers express virally encoded products, which are potential targets for anti-viral, tumor-specific therapies. In addition unique sets of cellular genes and pathways contribute to virally-associated cancers, many of which are currently being pursued as targets for anti-cancer therapies. This program project grant (PPG), now In its 35th year of continual funding, has two objectives: to use molecular biology and genetics to elucidate the life cycles of and transformation by human tumor viruses and to translate this understanding into the identification of targets for specific anti-viral, ant-tumor therapies. The PPG has seven senior investigators who share these research goals in studying human tumor viruses in three different virus families: papillomaviruses, hepadnaviruses and herpesviruses. Together, these three families of viruses cause the vast majority of virally-associated human cancers. Our PPG evolved over the current funding period to be composed of projects in which two or more investigators work together on a common theme in human tumor virology. Cross-fertilization of ideas and expertise between projects is fostered by having investigators work on multiple projects. This interactive and collaborative organization has been highly fruitful over th current funding period in several regards. Firstly, each project has been highly productive. Secondly, innovative new ideas and approaches have arisen many of which are now being used across multiple projects. Thirdly, the collaborative environment created by this PPG has spawned new interactions that are bringing additional expertise to the PPG. Most important of these interactions have been collaborations between Drs. Shannon Kenney and Rob Kalejta that have led to our including Dr. Kalejta as a new co-leader on two existing projects. The specific themes of this PPG are: 1) to identify and characterize cellular genes that drive human papillomavirus-associated cancer and modulate viral infection;2) to define the role of the hepatitis B virus core protein in multiple steps of the viral life cycle;3) to study the replicatin and inheritance of herpesviral genomes in relevant cell types using novel approaches for live cell imaging;4) to characterize cellular and viral factors that regulate the switch from the laten to lytic viral state of Epstein Barr virus (EBV);and 5) to define drivers of EBV-associated carcinogenesis and develop novel approaches for treating these cancers and diseases caused by herpesviruses.

Public Health Relevance

Viruses contribute to at least 20 different human cancers, representing approximately 15% of all human cancers. Understanding how the biology of these human tumor viruses and how they cause cancer will provide new approaches for preventing and treating the associated cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA022443-37
Application #
8675198
Study Section
Special Emphasis Panel (ZCA1-RPRB-2 (J1))
Program Officer
Daschner, Phillip J
Project Start
1997-02-01
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
37
Fiscal Year
2014
Total Cost
$2,001,744
Indirect Cost
$661,266
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Park, Soyeong; Park, Jung Wook; Pitot, Henry C et al. (2016) Loss of Dependence on Continued Expression of the Human Papillomavirus 16 E7 Oncogene in Cervical Cancers and Precancerous Lesions Arising in Fanconi Anemia Pathway-Deficient Mice. MBio 7:
Lee, Denis; Norby, Kathryn; Hayes, Mitchell et al. (2016) Using Organotypic Epithelial Tissue Culture to Study the Human Papillomavirus Life Cycle. Curr Protoc Microbiol 41:14B.8.1-14B.8.19
Bodelon, Clara; Vinokurova, Svetlana; Sampson, Joshua N et al. (2016) Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis 37:188-96
Unchwaniwala, Nuruddin; Sherer, Nathan M; Loeb, Daniel D (2016) Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal. J Virol 90:8705-19
Jones, Richard J; Iempridee, Tawin; Wang, Xiaobin et al. (2016) Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein-Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression. Clin Cancer Res 22:4901-4912
Zeng, Hao; Lu, Li; Chan, Ngai Ting et al. (2016) Systematic identification of Ctr9 regulome in ERα-positive breast cancer. BMC Genomics 17:902
Tan, Xiaojun; Lambert, Paul F; Rapraeger, Alan C et al. (2016) Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications. Trends Cell Biol 26:352-66
Makielski, Kathleen R; Lee, Denis; Lorenz, Laurel D et al. (2016) Human papillomavirus promotes Epstein-Barr virus maintenance and lytic reactivation in immortalized oral keratinocytes. Virology 495:52-62
Chiu, Ya-Fang; Sugden, Bill (2016) Epstein-Barr Virus: The Path from Latent to Productive Infection. Annu Rev Virol 3:359-372
Chandra, Janin; Kuo, Paula T Y; Hahn, Anne M et al. (2016) Batf3 selectively determines acquisition of CD8(+) dendritic cell phenotype and function. Immunol Cell Biol :

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