The Administration/Statistics (Admin/Stats) core provide two essential elements: oversight of the program project grant and expertise in statistics and bioinformatics. Oversight occurs at multiple levels, intellectual, administrative and financial. Intellectual oversight is achieved through multiple levels of interactions by the PI with Project leaders and their lab members, and with Core leaders. An external scientific board provides annual assessments of the program and advises Dr. Lambert of its findings. Administrative oversight is provided by Ms. Bette Sheehan, who has served this role for neariy 30 years helping to facilitate the multiple mechanisms of interaction as well as coordinating the training efforts of the members of each lab. Financial oversight is provided by Randy Martinson, who coordinates the management ofthe grant ensuring that monies are allocated appropriately and used efficiently to support the projects'and cores'needs. Ms. Sheehan and Mr Martinson report directly to Dr. Lambert. New to this competitive renewal is a statistics/bioinformatics section of this core that is led by Drs. Norman Drinkwater and Michael Newton. They will provide expertise in statistical analysis of animal/lab experiments as well as genome-wide analyses. Drs. Drinkwater and Newton have been supported during this current funding period on individual projects. We have transitioned to placing their expertise in the context of this core because their expertise is required now across all five projects. Dr. Lambert will oversee the successful integration of this new core activity into the PPG.

Public Health Relevance

Human viruses cause a multitude of human cancers. Understanding the biology of these viruses and their role in these cancers is essential for learning how to eradicate these cancers. This administrative core provides oversight over this program project grant at multiple levels as well as expertise in statistics and bioinformatics

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Special Emphasis Panel (ZCA1)
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University of Wisconsin Madison
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Park, Jung Wook; Nickel, Kwangok P; Torres, Alexandra D et al. (2014) Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. Radiother Oncol 113:337-44
Wang, Lu; Zhao, Zibo; Meyer, Mark B et al. (2014) CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis. Cancer Cell 25:21-36
Kuzembayeva, Malika; Hayes, Mitchell; Sugden, Bill (2014) Multiple functions are mediated by the miRNAs of Epstein-Barr virus. Curr Opin Virol 7:61-5
Wang, Joseph Che-Yen; Nickens, David G; Lentz, Thomas B et al. (2014) Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice. Proc Natl Acad Sci U S A 111:11329-34
Stein, Andrew P; Saha, Sandeep; Yu, Menggang et al. (2014) Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in the United States across time. Chem Res Toxicol 27:462-9
Iempridee, Tawin; Reusch, Jessica A; Riching, Andrew et al. (2014) Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. J Virol 88:4811-27
Park, J W; Shin, M-K; Lambert, P F (2014) High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. Oncogene 33:3383-91
Shrestha, Prabha; Sugden, Bill (2014) Identification of properties of the Kaposi's sarcoma-associated herpesvirus latent origin of replication that are essential for the efficient establishment and maintenance of intact plasmids. J Virol 88:8490-503
Vereide, D T; Seto, E; Chiu, Y-F et al. (2014) Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene 33:1258-64
Son, Jieun; Park, Jung Wook; Lambert, Paul F et al. (2014) Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. Carcinogenesis 35:489-96

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