The objective ofthe Administrative Core is to provide overall fiscal and scientific support for the Program Project grant. The Administrative Core interacts directly with each project and core in support of this goal. The administrative function of this Program Project involves the coordination and integration of the entire proposal. The Core maintains overall fiscal, as well as scientific responsibility and provides general day to day core support for the program. Dr. David Alberts has served as the Principal Investigator for this Program Project since 1989 and Director of Cancer Prevention and Control at the Arizona Cancer center from 1989 to 2004. Dr. Bowden is an internationally renowned basic scientist whose research interests focus on molecular mechanisms and prevention of skin carcinogenesis. As Principal Investigator, he brings leadership to the basic science components of the grant as well as translation of these basic science findings to the clinical trials. He shares overall fiscal and scientific responsibility with Dr. Alberts. Rayna Goldman, MBA has been the chief administrator for this program project grant since the mid-1980s and her strong business experience has been invaluable to its success. The Administrative Core works closely with the Cancer Center Business Office accountants to ensure that timely budget updates are provided to all investigators. The Administrative Core initiates subcontracts with other institutions. It then reviews invoices and documentation prior to payment to the subcontracts. It approves and allocates funds to support consultants, travel, and publication costs forthe grant and it works with the investigators, the CancerCenter Business Office accountants, and the University of Arizona Sponsored Projects staff to ensure appropriate expenditure of grant funds. The administrative Core schedules twice monthly Program Project meetings to facilitate communication and research collaboration with faculty, staff, and consultants. Additionally, the Scientific Advisory Board and the External Data Safety Monitoring Committee meet annually. These meetings and/or teleconferences are coordinated by the Administrative Core and are essential to ensuring communication and collaboration. Core administrative staff are responsible for reporting activity to the University of Arizona's IRB and the NIH. They also serve as an administrative and research resource to the project and core investigators and staff. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions of the decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.

Public Health Relevance

The primary goal of the Chemoprevention of Skin Cancer Program Project is to develop novel agents that can hit multiple solar UV signal transduction pathways, thereby stopping the progression of precancerous lesions in the skin to skin cancers. Reducing the incidence of these dangerous cancers would not only reduce the potentially severe morbidity and mortality associated with these cancers, but also dramatically reduce the multibillion dollar health bill associated with the surgical and medical treatments required for skin cancers. The Administrative Core supports the investigators of this Program Project in this important work by providing overall administrative and fiscal support.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arizona
United States
Zip Code
Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931
Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82
Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1:
Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854
Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6
Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919
Peng, C; Zeng, W; Su, J et al. (2016) Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. Oncogene 35:1170-9
Curiel-Lewandrowski, Clara; Swetter, Susan M (2016) Lack of harms from community-based melanoma screening by primary care providers. Cancer 122:3102-3105
Dickinson, Sally E; Janda, Jaroslav; Criswell, Jane et al. (2016) Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin. Cancer Prev Res (Phila) 9:215-24
Bode, Ann M; Dong, Zigang; Wang, Hongyang (2016) Cancer prevention and control: alarming challenges in China. Natl Sci Rev 3:117-127

Showing the most recent 10 out of 390 publications