The objective ofthe Administrative Core is to provide overall fiscal and scientific support for the Program Project grant. The Administrative Core interacts directly with each project and core in support of this goal. The administrative function of this Program Project involves the coordination and integration of the entire proposal. The Core maintains overall fiscal, as well as scientific responsibility and provides general day to day core support for the program. Dr. David Alberts has served as the Principal Investigator for this Program Project since 1989 and Director of Cancer Prevention and Control at the Arizona Cancer center from 1989 to 2004. Dr. Bowden is an internationally renowned basic scientist whose research interests focus on molecular mechanisms and prevention of skin carcinogenesis. As Principal Investigator, he brings leadership to the basic science components of the grant as well as translation of these basic science findings to the clinical trials. He shares overall fiscal and scientific responsibility with Dr. Alberts. Rayna Goldman, MBA has been the chief administrator for this program project grant since the mid-1980s and her strong business experience has been invaluable to its success. The Administrative Core works closely with the Cancer Center Business Office accountants to ensure that timely budget updates are provided to all investigators. The Administrative Core initiates subcontracts with other institutions. It then reviews invoices and documentation prior to payment to the subcontracts. It approves and allocates funds to support consultants, travel, and publication costs forthe grant and it works with the investigators, the CancerCenter Business Office accountants, and the University of Arizona Sponsored Projects staff to ensure appropriate expenditure of grant funds. The administrative Core schedules twice monthly Program Project meetings to facilitate communication and research collaboration with faculty, staff, and consultants. Additionally, the Scientific Advisory Board and the External Data Safety Monitoring Committee meet annually. These meetings and/or teleconferences are coordinated by the Administrative Core and are essential to ensuring communication and collaboration. Core administrative staff are responsible for reporting activity to the University of Arizona's IRB and the NIH. They also serve as an administrative and research resource to the project and core investigators and staff. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions of the decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.
The primary goal of the Chemoprevention of Skin Cancer Program Project is to develop novel agents that can hit multiple solar UV signal transduction pathways, thereby stopping the progression of precancerous lesions in the skin to skin cancers. Reducing the incidence of these dangerous cancers would not only reduce the potentially severe morbidity and mortality associated with these cancers, but also dramatically reduce the multibillion dollar health bill associated with the surgical and medical treatments required for skin cancers. The Administrative Core supports the investigators of this Program Project in this important work by providing overall administrative and fiscal support.
|Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20|
|Glazer, Evan S; Hornbrook, Mark C; Krouse, Robert S (2014) A meta-analysis of randomized trials: immediate stent placement vs. surgical bypass in the palliative management of malignant biliary obstruction. J Pain Symptom Manage 47:307-14|
|Williams, Joshua D; Bermudez, Yira; Park, Sophia L et al. (2014) Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue. J Photochem Photobiol B 132:56-65|
|Sheng, Yuqiao; Li, Wei; Zhu, Feng et al. (2014) 3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer. J Biol Chem 289:28192-201|
|Lim, Tae-Gyu; Lee, Sung-Young; Huang, Zunnan et al. (2014) Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prev Res (Phila) 7:466-74|
|Wen, W; Peng, C; Kim, M O et al. (2014) Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene 33:421-8|
|Lim, Do Young; Lee, Mee-Hyun; Shin, Seung Ho et al. (2014) (+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38. Cancer Prev Res (Phila) 7:856-65|
|Yao, Ke; Chen, Hanyong; Liu, Kangdong et al. (2014) Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prev Res (Phila) 7:958-67|
|Dickinson, Sally E; Olson, Erik R; Levenson, Corey et al. (2014) A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes. Arch Biochem Biophys 558:143-52|
|Franklin, Stephen J; Dickinson, Sally E; Karlage, Kelly L et al. (2014) Stability of sulforaphane for topical formulation. Drug Dev Ind Pharm 40:494-502|
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