Dr. Luis Eduardo Bravo is the Principal Investigator and supervises all activities in Colombia. He is based in Cali and travels often to Pasto. His administrative assistant in Cali is Mr. Tito Collazos who has been the administrator for all the life of the Program Project. Mr. Collazos coordinates the clinical work conducted at Hospital Departamental of Pasto and Hospital San Andres in Tumaco. He also collaborates with Nurse Maria Clara Yepez, in-charge of the children's cohorts at Universidad de Narino. Dr. Bravo's data manager assistant is Mrs. Stella Garcia, who has been in charge of those activities for approximately 10 years and has become extraordinarily skilled and efficient. The data generated in Pasto are entered and edited by Mrs. Alicia Rosero, who also has been conducting these activities very efficiently for years. Mrs. Rosero transmits the data via internet to Nashville and Raleigh, NC for Dr. Robertino Mera. The field team in Narino is under the direction of Dr. Guillermo Zarama, who is also the gastroenterologist and endoscopist in charge. He is based at Hospital Departamental. The field team is based at Universidad de Narino (Pasto) under the direction of Nurse Maria Clara Yepez. She has trained outstanding assistants (nurses-social workers). Mrs. Cristina Campo supervises the clinical nursing and data managing team in Narino. Dr. Juan Carios Bravo is assistant pathologist for gastric biopsies interpretation. The biopsies are fixed and embedded in paraffin in Colombia. A first section is stained and used for diagnostic uses communicated to the clinician. The paraffin blocks are then transported to Nashville for further processing, immunohistochemistry, and other special procedures.

Public Health Relevance

In Colombia there are unique subpopulations, not available in the United States, displaying marked contrasts in terms of risk of gastric cancer and infection with the bacterium Helicobacter pylori, a recognized cause of gastric cancer. The infrastructure to study such populations has been developed over the years and is very efficient.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028842-27
Application #
8379238
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
27
Fiscal Year
2012
Total Cost
$162,604
Indirect Cost
$41,400
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Bravo, Luis Eduardo; García, Luz Stella; Collazos, Paola et al. (2018) Reliable information for cancer control in Cali, Colombia. Colomb Med (Cali) 49:23-34
Mera, Robertino M; Bravo, Luis E; Camargo, M Constanza et al. (2018) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67:1239-1246
García, Luz Stella; Bravo, Luis Eduardo; Collazos, Paola et al. (2018) Cali cancer registry methods. Colomb Med (Cali) 49:109-120
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Ge, Zhongming; Sheh, Alexander; Feng, Yan et al. (2018) Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses. Sci Rep 8:8014
Gobert, Alain P; Al-Greene, Nicole T; Singh, Kshipra et al. (2018) Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front Immunol 9:1242
Estevez-Ordonez, Dagoberto; Montalvan-Sanchez, Eleazar E; Wong, Rochelle E et al. (2018) Health Barriers and Patterns of Gastric Cancer Care in Rural Central American Resource-Limited Settings. JAMA Oncol 4:1131-1133
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Sierra, Johanna C; Asim, Mohammad; Verriere, Thomas G et al. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67:1247-1260
Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517

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