Dr. Luis Eduardo Bravo is the Principal Investigator and supervises all activities in Colombia. He is based in Cali and travels often to Pasto. His administrative assistant in Cali is Mr. Tito Collazos who has been the administrator for all the life of the Program Project. Mr. Collazos coordinates the clinical work conducted at Hospital Departamental of Pasto and Hospital San Andres in Tumaco. He also collaborates with Nurse Maria Clara Yepez, in-charge of the children's cohorts at Universidad de Narino. Dr. Bravo's data manager assistant is Mrs. Stella Garcia, who has been in charge of those activities for approximately 10 years and has become extraordinarily skilled and efficient. The data generated in Pasto are entered and edited by Mrs. Alicia Rosero, who also has been conducting these activities very efficiently for years. Mrs. Rosero transmits the data via internet to Nashville and Raleigh, NC for Dr. Robertino Mera. The field team in Narino is under the direction of Dr. Guillermo Zarama, who is also the gastroenterologist and endoscopist in charge. He is based at Hospital Departamental. The field team is based at Universidad de Narino (Pasto) under the direction of Nurse Maria Clara Yepez. She has trained outstanding assistants (nurses-social workers). Mrs. Cristina Campo supervises the clinical nursing and data managing team in Narino. Dr. Juan Carios Bravo is assistant pathologist for gastric biopsies interpretation. The biopsies are fixed and embedded in paraffin in Colombia. A first section is stained and used for diagnostic uses communicated to the clinician. The paraffin blocks are then transported to Nashville for further processing, immunohistochemistry, and other special procedures.

Public Health Relevance

In Colombia there are unique subpopulations, not available in the United States, displaying marked contrasts in terms of risk of gastric cancer and infection with the bacterium Helicobacter pylori, a recognized cause of gastric cancer. The infrastructure to study such populations has been developed over the years and is very efficient.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028842-28
Application #
8540098
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
28
Fiscal Year
2013
Total Cost
$152,111
Indirect Cost
$38,847
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Garay, Jone; Piazuelo, M Blanca; Majumdar, Sumana et al. (2016) The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Cancer Lett 371:90-8
Murray-Stewart, T; Sierra, J C; Piazuelo, M B et al. (2016) Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Oncogene 35:5480-5488
Yang, Ines; Woltemate, Sabrina; Piazuelo, M Blanca et al. (2016) Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Sci Rep 6:18594
Sobota, Rafal S; Kodaman, Nuri; Mera, Robertino et al. (2016) Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Hum Genet 135:895-906
Esmail, Michael Y; Bacon, Rebecca; Swennes, Alton G et al. (2016) Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma. Helicobacter 21:175-85
Camargo, M Constanza; Kim, Kyoung-Mee; Matsuo, Keitaro et al. (2016) Anti-Helicobacter pylori Antibody Profiles in Epstein-Barr virus (EBV)-Positive and EBV-Negative Gastric Cancer. Helicobacter 21:153-7
Dubeykovskaya, Zina; Si, Yiling; Chen, Xiaowei et al. (2016) Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nat Commun 7:10517
Singh, Kshipra; Al-Greene, Nicole T; Verriere, Thomas G et al. (2016) The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog 12:e1005984
Dixon, Beverly R E A; Radin, Jana N; Piazuelo, M Blanca et al. (2016) IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori. PLoS One 11:e0148514
Hardbower, Dana M; Asim, Mohammad; Murray-Stewart, Tracy et al. (2016) Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Amino Acids :

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