Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028852-05
Application #
4691158
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
Lazo, J S; Schisselbauer, J C; Meandzija, B et al. (1989) Initial single-strand DNA damage and cellular pharmacokinetics of bleomycin A2. Biochem Pharmacol 38:2207-13
Narayanan, R; Jastreboff, M M; Chiu, C F et al. (1988) A method to detect transfected chloramphenicol acetyltransferase gene expression in intact animals. Exp Cell Res 174:297-301
Lin, T S; Guo, J Y; Schinazi, R F et al. (1988) Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). J Med Chem 31:336-40
Lin, T S; Zhang, X H; Wang, Z H et al. (1988) Synthesis and antiviral evaluation of carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine. J Med Chem 31:484-6
Hait, W N; Lazo, J S; Chen, D L et al. (1988) Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent. J Natl Cancer Inst 80:246-50
Lin, T S; Schinazi, R F; Chen, M S et al. (1987) Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro. Biochem Pharmacol 36:311-6
Darnowski, J W; Holdridge, C; Handschumacher, R E (1987) Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency. Cancer Res 47:2614-9
Lin, T S; Chen, M S; McLaren, C et al. (1987) Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses. J Med Chem 30:440-4
Lin, T S; Schinazi, R F; Prusoff, W H (1987) Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus. Biochem Pharmacol 36:2713-8
Jastreboff, M M; Sokoloski, J A; Bertino, J R et al. (1987) Use of electroporation to study the cytotoxic effects of fluorodeoxyuridylate in intact cells. Biochem Pharmacol 36:1345-8

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