The objectives of the Administrative and Statistical Core are to continue to provide overall administrative direction and statistical support for all aspects ofthe PPG Program. The services will include the following: 1. To assist in the biostatistical design of experiments in all of the projects with respect to sample size and potential differences between groups 2. To assist in the biostatistical analysis of laboratory data, particulariy where large amounts of information are generated (e.g. proteomics data) 3. To facilitate optimal interactions among all projects and cores 4. To coordinate meetings and communication among the Executive Committee members 5. To coordinate and facilitate the input of members ofthe Scientific Advisory Board, including meetings and travel arrangements 6. To provide administrative support to the investigators, including secretarial, personnel management, and document generation 7. To provide support and administration for appropriate centralized data sharing for the proposed projects, including document generation and organization and documentation of requests. 8. To manage all financial aspects of the grant 9. To work with internal and external institutions and agencies to ensure appropriate administrative documentation, communication, and accountability

Public Health Relevance

Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, GVHD. Strategies that mitigate GVHD will allow for better harnessing of this effective therapeutic modality to treat many patients with hematological cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA039542-26
Application #
8545542
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
26
Fiscal Year
2013
Total Cost
$167,181
Indirect Cost
$87,438
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Glick, Gary D; Rossignol, Rodrigue; Lyssiotis, Costas A et al. (2014) Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease. J Pharmacol Exp Ther 351:298-307
Choi, Sung Won; Braun, Thomas; Chang, Lawrence et al. (2014) Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol 15:87-95
Vander Lugt, Mark T; Braun, Thomas M; Hanash, Samir et al. (2013) ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med 369:529-39
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Byersdorfer, Craig A; Tkachev, Victor; Opipari, Anthony W et al. (2013) Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood 122:3230-7
Levine, John E; Huber, Elisabeth; Hammer, Suntrea T G et al. (2013) Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality. Blood 122:1505-9
Harris, Andrew C; Kitko, Carrie L; Couriel, Daniel R et al. (2013) Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes. Haematologica 98:179-84
Brown, J R; Kim, H T; Armand, P et al. (2013) Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome. Leukemia 27:362-9
Paczesny, Sophie (2013) Discovery and validation of graft-versus-host disease biomarkers. Blood 121:585-94

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