This grant will be under the administrative cognizance of the Department of Radiology within the School of Medicine. The department is professionally supported by the School of Medicine staff and the central university Office of Sponsored Programs. The co-PIs of the POI, KA Krohn and JF Eary, meet weekly with the project and core directors to review the progress of the research and to insure effective use of core resources by scheduling imaging studies. In addition, the administrative core will include support for patient imaging and regulatory compliance as well as data sharing via caBIG and archiving images with NCI.

Public Health Relevance

This core provides important organization to a program that is spread over several departments and two campuses. The imaging instrumentation at UWMC and SCCA is essential for each of our projects and a coordinated effort for data sharing will help integrate this program with our Comprehensive Cancer Center and with the NCI Cancer Imaging Program.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01CA042045-25
Application #
8722458
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Huang, Jian; O'Sullivan, Finbarr (2014) An analysis of whole body tracer kinetics in dynamic PET studies with application to image-based blood input function extraction. IEEE Trans Med Imaging 33:1093-108
O'Sullivan, Finbarr; Muzi, Mark; Mankoff, David A et al. (2014) VOXEL-LEVEL MAPPING OF TRACER KINETICS IN PET STUDIES: A STATISTICAL APPROACH EMPHASIZING TISSUE LIFE TABLES. Ann Appl Stat 8:1065-1094
Zhou, Dong; Lin, Mai; Yasui, Norio et al. (2014) Optimization of the preparation of fluorine-18-labeled steroid receptor ligands 16alpha-[18F]fluoroestradiol (FES), [18F]fluoro furanyl norprogesterone (FFNP), and 16beta-[18F]fluoro-5alpha-dihydrotestosterone (FDHT) as radiopharmaceuticals. J Labelled Comp Radiopharm 57:371-7
Eary, Janet F; Krohn, Kenneth A (2013) Standards for reporting PET clinical trials. J Nucl Med 54:1516-7
Eary, Janet F; Link, Jeanne M; Muzi, Mark et al. (2011) Multiagent PET for risk characterization in sarcoma. J Nucl Med 52:541-6
Peterson, Lanell M; Kurland, Brenda F; Link, Jeanne M et al. (2011) Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer. Nucl Med Biol 38:969-78
Kurland, Brenda F; Peterson, Lanell M; Lee, Jean H et al. (2011) Between-patient and within-patient (site-to-site) variability in estrogen receptor binding, measured in vivo by 18F-fluoroestradiol PET. J Nucl Med 52:1541-9
Hendrickson, Kristi; Phillips, Mark; Smith, Wade et al. (2011) Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance. Radiother Oncol 101:369-75
Linden, Hannah M; Kurland, Brenda F; Peterson, Lanell M et al. (2011) Fluoroestradiol positron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin Cancer Res 17:4799-805
Dunnwald, Lisa K; Doot, Robert K; Specht, Jennifer M et al. (2011) PET tumor metabolism in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy: value of static versus kinetic measures of fluorodeoxyglucose uptake. Clin Cancer Res 17:2400-9

Showing the most recent 10 out of 160 publications