This core will provide support for administrative management and research coordination of the entire program project grant. Administrative support (management of personnel and fiscal matters) on an ongoing basis is required for the successful performance of this program project grant. Our program is an integrated multi departmental effort, which spans several disciplines. These include medical oncology, radiation oncology, pulmonary medicine, immunology, infectious diseases including virology, and pathology. The preclinical and clinical studies are contributed by scientists from these disciplines in each of the projects with support by the two cores of this grant application. Efficient integration of these efforts requires a major effort in coordination and collaboration. Core A is intended to optimize the interaction between all participating investigators. Administrative support includes also communication between the investigator and the institutional review bodies, external consultants, governmental review groups and NIH officials. Core A will serve to coordinate all efforts to maintain data accrual from referring physicians and from patients after discharge from the bone marrow transplantation unit, including longitudinal evaluations of recipients in an organized manner.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA047741-20
Application #
8539268
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$143,070
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Brunger, Jonathan M; Huynh, Nguyen P T; Guenther, Caitlin M et al. (2014) Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proc Natl Acad Sci U S A 111:E798-806
Kanda, Junya; Long, Gwynn D; Gasparetto, Cristina et al. (2014) Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies. Biol Blood Marrow Transplant 20:257-63
Brandstadter, Joshua D; Huang, Xiaopei; Yang, Yiping (2014) NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus. Eur J Immunol 44:2659-66
Macintyre, Andrew N; Gerriets, Valerie A; Nichols, Amanda G et al. (2014) The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab 20:61-72
Horwitz, Mitchell E; Chao, Nelson J; Rizzieri, David A et al. (2014) Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest 124:3121-8
Glass, Katherine A; Link, Jarrett M; Brunger, Jonathan M et al. (2014) Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Biomaterials 35:5921-31
Chen, Benny J; Jiao, Yiqun; Zhang, Ping et al. (2013) Long-term in vivo imaging of multiple organs at the single cell level. PLoS One 8:e52087
Kanda, J; Kaynar, L; Kanda, Y et al. (2013) Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. Bone Marrow Transplant :
Fortin, Carl; Huang, Xiaopei; Yang, Yiping (2013) Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus. J Immunol 191:363-8
Kanda, J; Horwitz, M E; Long, G D et al. (2012) Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 47:700-5

Showing the most recent 10 out of 92 publications