The Technical Core has and continues to play a central role in this Program Project. In the context of the overall Program Project themes, the Technical Core acts as an integrative tool to facilitate consistent experimental design and data analyses, across the three projects, as well as providing microbeam irradiation facilities. There are five main Core functions for this Technical Core: 1. Provide experimental design support based on Monte Carlo simulation for the three projects, to optimize resource utilization for resource-intensive experiments. 2. Provide consistent and rigorous statistical and data analysis support. 3. Obtaining and interpreting global gene-expression data. 4. Support for the POl-related operations ofthe accelerator-based single-cell / single-particle microbeam, and track-segment charged-particle irradiations. 5. Provide expertise in the design and fabrication of special irradiation fixtures, through the Center for Radiological Research Instrument Shop.

Public Health Relevance

The overall objectives of this program project application are to define and characterize the mechanisms of the bystander effect, and probe its implications. Three well linked, fully integrated projects are proposed to address these issues, and will be supported by the five key functions ofthe Technical Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA049062-23
Application #
8693585
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
23
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Wu, Jinhua; Zhang, Qin; Wuu, Yen-Ruh et al. (2017) Cytoplasmic Irradiation Induces Metabolic Shift in Human Small Airway Epithelial Cells via Activation of Pim-1 Kinase. Radiat Res 187:441-453
Liao, Wupeng; Hei, Tom K; Cheng, Simon K (2017) Radiation-Induced Dermatitis is Mediated by IL17-Expressing ?? T Cells. Radiat Res 187:454-464
Wu, Jinhua; Zhang, Bo; Wuu, Yen-Ruh et al. (2017) Targeted cytoplasmic irradiation and autophagy. Mutat Res 806:88-97
Chen, Hongxin; Chong, Zhao Zhong; De Toledo, Sonia M et al. (2016) Delayed activation of human microglial cells by high dose ionizing radiation. Brain Res 1646:193-198
Gong, Xuezhong; Ivanov, Vladimir N; Hei, Tom K (2016) 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-?B, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol 90:2187-200
Azzam, Edouard I; Colangelo, Nicholas W; Domogauer, Jason D et al. (2016) Is Ionizing Radiation Harmful at any Exposure? An Echo That Continues to Vibrate. Health Phys 110:249-51
Hei, Tom K (2016) Response of Biological Systems to Low Doses of Ionizing Radiation. Health Phys 110:281-2
Ivanov, Vladimir N; Hei, Tom K (2015) Regulation of viability, differentiation and death of human melanoma cells carrying neural stem cell biomarkers: a possibility for neural trans-differentiation. Apoptosis 20:996-1015
Dong, Chen; He, Mingyuan; Tu, Wenzhi et al. (2015) The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation. Cancer Lett 363:92-100
Liu, Jing; Fang, Hongbo; Chi, Zhenfen et al. (2015) XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage. Nucleic Acids Res 43:5476-88

Showing the most recent 10 out of 218 publications