Abstract

The major goals of this core are: 1) to compare the utilities of interphase FISH, hypermetaphase FISH, and RT-PCR in their abilities to predict prognosis, monitor therapy responses, and predict relapse, and 2) to support the gene mapping studies needed for Dr. Lalitha Nagarajan to define the critical regions on chromosome 7 that are responsible for poor prognosis of 7q- patients. This core will perform 1) FISH on interphase nuclei to detect leukemic cells with chromosomal translocations such as t(15;17) and t(9;22), 2) develop interphase probes for inv (16) and t(8;21) in collaboration with Drs. Siciliano, Claxton and Chang, and develop interphase probes for 5q- and 7q- in collaboration with Dr. Nagarajan to correlate iFISH results with hypermetaphase FISH (HMF) and RT-PCR to support the FISH studies needed for gene mapping on chromosome 7 to define the critical regions on this chromosome that are responsible for poor prognosis (Dr. Lalitha Nagarajan). This core will collaborate with Dr. Elihu Estey to monitor therapy responses, Dr. Richard Champlin to monitor responses to BMT, Dr. Christopher Reading to enrich diploid stem cells, correlate iFISH, HMF, and RT-PCR, and Dr. Lalitha Nagarajan to map the critical regions on chromosome 7 that are responsible for poor prognosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA055164-08
Application #
6102718
Study Section
Project Start
1999-06-07
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Ruvolo, Peter P; Ruvolo, Vivian R; Burks, Jared K et al. (2018) Role of MSC-derived galectin 3 in the AML microenvironment. Biochim Biophys Acta Mol Cell Res 1865:959-969
Ngankeu, Apollinaire; Ranganathan, Parvathi; Havelange, Violaine et al. (2018) Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia. Oncotarget 9:4354-4365
Le, Phuong M; Andreeff, Michael; Battula, Venkata Lokesh (2018) Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis. Haematologica :
Jiang, Xuejie; Mak, Po Yee; Mu, Hong et al. (2018) Disruption of Wnt/?-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia. Clin Cancer Res 24:2417-2429
Ishizawa, Jo; Nakamaru, Kenji; Seki, Takahiko et al. (2018) Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition. Cancer Res 78:2721-2731
Sekihara, Kazumasa; Saitoh, Kaori; Han, Lina et al. (2017) Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Oncotarget 8:34552-34564
Carter, Bing Z; Mak, Po Yee; Wang, Xiangmeng et al. (2017) Focal Adhesion Kinase as a Potential Target in AML and MDS. Mol Cancer Ther 16:1133-1144
Zeng, Zhihong; Liu, Wenbin; Tsao, Twee et al. (2017) High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia. Haematologica 102:1537-1548
Pan, Rongqing; Ruvolo, Vivian; Mu, Hong et al. (2017) Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer Cell 32:748-760.e6
Jacamo, Rodrigo; Davis, R Eric; Ling, Xiaoyang et al. (2017) Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia. Oncotarget 8:83354-83369

Showing the most recent 10 out of 422 publications