Public Health Relevance

PDT is a clinically useful cancer therapy. Its further improvement requires the rational design of nextgeneration single and multifunctional PS which may be combined with secondary agents to enhance efficacy and selectivity. The secondary agents may influence tissue and cell distribution and pharmacokinetics (PK) of the PS. The studies described in this Core are crucial to determine the appropriate dosing schedules and treatment regimens of the modified PS for the best outcome and the clinical advancement of PDT.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA055791-20
Application #
8462218
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
20
Fiscal Year
2013
Total Cost
$184,366
Indirect Cost
$74,138
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
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Mimikos, Christina; Shafirstein, Gal; Arshad, Hassan (2016) Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma. World J Otorhinolaryngol Head Neck Surg 2:126-129
Patel, Nayan; Pera, Paula; Joshi, Penny et al. (2016) Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer. J Med Chem 59:9774-9787

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