Core B Photodynamic therapy (PDT) is activated by light, and the tumors that are treated by PDT are accessible to light either directly or via optical fibers advanced through needles or catheters. Thus optics plays a central role in planning and administering PDT and in monitoring response to therapy. The Optics Core of this program project supports the optics and physics needs of all of the projects with particular emphasis on facilitating the definitive clinical trials in head and neck cancer. Toward these ends, we have proposed the following three specific aims: (1) To acquire, characterize, disseminate, and support the commercial Zenascope spectroscopy system for the multi-center trials of HPPH-PDT in (i) T1/T2 N0 tumors of the oral cavity and oropharynx (Project I, Specific Aim 1) and (ii) patients with locally advanced recurrent HNSCC who have failed radiation (Project 1, Specific Aim 2). In the first of these trials, spectroscopy will be used to evaluate possible predictors of treatment response. In the second trial, optical properties derived from reflectance measurements will be incorporated into PDT treatment plans. Reflectance spectroscopy was used successfully at RPCI in the oral cavity PDT clinical trial of the previous funding period. Zenascope reflectance spectroscopy systems will be placed at the four participating clinical trial sites. The Core will support these systems, train users at Rochester, Johns Hopkins, Minnesota, and RPCI, and be responsible for data analysis and interpretation; (2) To provide and further optimize image-based interstitial PDT treatment planning for a multi-center Phase II trial of HPPH-PDT in patients with locally advanced recurrent HNSCC who have failed radiation (Project 1, Specific Aim 2). Target volumes and surrounding normal structures defined on patient CT scans will be incorporated into treatment planning simulation codes. Informed by pre-treatment measurements of tumor optical properties, an initial treatment plan will be created. The plan will be evaluated based on interstitial fluence measurements using a dosimetry system developed at RPCI; and (3) To provide routine engineering and optics support for the clinical and preclinical research efforts of the program project. These responsibilities include technical support for the clinical and preclinical lasers at RPCI and the fabrication and maintenance of fiber delivery systems.

Public Health Relevance

Photodynamic therapy (PDT) is a form of cancer treatment in which drugs are activated by light at the tumor site. Our experience suggests that PDT has much to offer to head and neck cancer patients. The Optics Core of the program project provides engineering and physics support for the optical systems used to deliver PDT and to perform measurements and simulations that aid in treatment planning and in predicting the response to therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA055791-24
Application #
9421476
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
24
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Egan, Shawn M; Karasik, Ellen; Ellis, Leigh et al. (2017) miR-30e* is overexpressed in prostate cancer and promotes NF-?B-mediated proliferation and tumor growth. Oncotarget 8:67626-67638
Hall, Brandon M; Balan, Vitaly; Gleiberman, Anatoli S et al. (2017) p16(Ink4a) and senescence-associated ?-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli. Aging (Albany NY) 9:1867-1884
Oakley, Emily; Bellnier, David A; Hutson, Alan et al. (2017) Surface markers for guiding cylindrical diffuser fiber insertion in interstitial photodynamic therapy of head and neck cancer. Lasers Surg Med 49:599-608
Saenz, Courtney; Cheruku, Ravindra R; Ohulchanskyy, Tymish Y et al. (2017) Structural and Epimeric Isomers of HPPH [3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a]: Effects on Uptake and Photodynamic Therapy of Cancer. ACS Chem Biol 12:933-946
Mimikos, Christina; Shafirstein, Gal; Arshad, Hassan (2016) Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma. World J Otorhinolaryngol Head Neck Surg 2:126-129
Patel, Nayan; Pera, Paula; Joshi, Penny et al. (2016) Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer. J Med Chem 59:9774-9787
Jenkins, Samir V; Srivatsan, Avinash; Reynolds, Kimberly Y et al. (2016) Understanding the interactions between porphyrin-containing photosensitizers and polymer-coated nanoparticles in model biological environments. J Colloid Interface Sci 461:225-31
Shafirstein, Gal; Battoo, Athar; Harris, Kassem et al. (2016) Photodynamic Therapy of Non-Small Cell Lung Cancer. Narrative Review and Future Directions. Ann Am Thorac Soc 13:265-75
Rohrbach, Daniel J; Rigual, Nestor; Arshad, Hassan et al. (2016) Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma. J Biomed Opt 21:18002
Shafirstein, Gal; Rigual, Nestor R; Arshad, Hassan et al. (2016) Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study. Head Neck 38 Suppl 1:E377-83

Showing the most recent 10 out of 163 publications