The Microscopy and Molecular Cytochemistry Core (Core C) will provide instrumentation, expertise and service as related to microscopy, cytochemistry, immunocytochemistry, cytopathology, histochemistry and photography as needed by each of the four project components. This core will provide the following specific functions; (1) instrumentation and technical expertise on conventional bright field and epifluorescence microscopy, Laser Scanning Confocal Microscopy and image analysis, (2) hist and cytochemistry, immunocytochemistry, paraffin and frozen sections, special staining procedures, and in situ hybridization, (3) electron microscopy and, (4) photography including black and white or color prints, development of 35 mm film, darkroom procedures and photographic copying and macro-photography of dyeinjected mammary glands and whole animals. The core leader and personnel will be available to provide assistance and advice on experimental designs as related to any technique or procedure in microscopy and cytochemistry.
| Medina, Daniel; Kittrell, Frances; Hill, Jamal et al. (2009) Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib. Cancer Prev Res (Phila) 2:168-74 |
| Medina, D; Kittrell, F S; Tsimelzon, A et al. (2007) Inhibition of mammary tumorigenesis by estrogen and progesterone in genetically engineered mice. Ernst Schering Found Symp Proc :109-26 |
| Caulin, Carlos; Nguyen, Thao; Lang, Gene A et al. (2007) An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest 117:1893-901 |
| Goepfert, Thea M; Moreno-Smith, Myrthala; Edwards, David G et al. (2007) Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer 120:985-94 |
| Rajkumar, Lakshmanaswamy; Kittrell, Frances S; Guzman, Raphael C et al. (2007) Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res 9:R12 |
| Ginger, Melanie R; Shore, Amy N; Contreras, Alejandro et al. (2006) A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci U S A 103:5781-6 |
| Sharp, Z Dave; Mancini, Maureen G; Hinojos, Cruz A et al. (2006) Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci 119:4101-16 |
| Medina, Daniel (2005) Mammary developmental fate and breast cancer risk. Endocr Relat Cancer 12:483-95 |
| Ginger, Melanie R; Rosen, Jeffrey M (2003) Pregnancy-induced changes in cell-fate in the mammary gland. Breast Cancer Res 5:192-7 |
| Stenoien, D L; Sen, S; Mancini, M A et al. (2003) Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton 55:134-46 |
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