The Animal Resources Core will provide a centralized management for all research projects utilizing rats. This Core will be responsible for ordering and care of rats, all procedures administered to rats, tissue preparation, allocation and storage, mammary gland transplantations and injections, intraduct injections and monitor and maintenance of transgenic rats. The Core will provide quality control and uniformity of all animal- related procedures which will yield a significant savings and uniform results. The Core will be headed by Dr. Susanne Krnacik and assisted by Dr. Daniel Medina.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA064255-04
Application #
6269662
Study Section
Project Start
1998-06-01
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Medina, Daniel; Kittrell, Frances; Hill, Jamal et al. (2009) Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib. Cancer Prev Res (Phila) 2:168-74
Medina, D; Kittrell, F S; Tsimelzon, A et al. (2007) Inhibition of mammary tumorigenesis by estrogen and progesterone in genetically engineered mice. Ernst Schering Found Symp Proc :109-26
Caulin, Carlos; Nguyen, Thao; Lang, Gene A et al. (2007) An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest 117:1893-901
Goepfert, Thea M; Moreno-Smith, Myrthala; Edwards, David G et al. (2007) Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer 120:985-94
Rajkumar, Lakshmanaswamy; Kittrell, Frances S; Guzman, Raphael C et al. (2007) Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res 9:R12
Ginger, Melanie R; Shore, Amy N; Contreras, Alejandro et al. (2006) A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci U S A 103:5781-6
Sharp, Z Dave; Mancini, Maureen G; Hinojos, Cruz A et al. (2006) Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci 119:4101-16
Medina, Daniel (2005) Mammary developmental fate and breast cancer risk. Endocr Relat Cancer 12:483-95
Ginger, Melanie R; Rosen, Jeffrey M (2003) Pregnancy-induced changes in cell-fate in the mammary gland. Breast Cancer Res 5:192-7
Stenoien, D L; Sen, S; Mancini, M A et al. (2003) Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton 55:134-46

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