The utilization of genetically engineered mouse (GEIVI) strains is an integral component of this GTBT P01 program project. The mouse model Core will provide all the necessary expertise, reagents and services for the analysis of exosomal biology with regards to therapeutic applications in GEM models of GBM. The services and reagents provided by this Core will synergize with the individual Projects on the validation and assessment of exosomal-associated molecular biomarkers and the application of cutting edge monitoring technologies for tumor response to therapeutic agents. In addition, the Core will produce and characterize three new GBM GEM strains over the funding period. As such, the Core will support all aspects of the construction of these new transgenic mouse models, including advice, service, technologies and reagents for the optimal design and construction of each specific strain. Using these new strains, the Core will also evaluate and implement new technologies for the detection and monitoring of various exosomal metrics in close relationship with the individual Projects.

Public Health Relevance

The goal of this Core is to provide technical and intellectual support for the use of genetically engineered mouse models of GBM as a conduit for monitoring tumor growth response in relation to therapeutic intervention using exosome-based detection and content analysis

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA069246-15A1
Application #
8237579
Study Section
Special Emphasis Panel (ZCA1-GRB-P (O1))
Project Start
Project End
Budget Start
2012-05-29
Budget End
2013-04-30
Support Year
15
Fiscal Year
2012
Total Cost
$258,583
Indirect Cost
$68,857
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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