Core A (Administration) will have overall responsibility for: (A). Administration of the Program Project: """"""""Experimental Therapeutics and BioMonitoring for Brain Tumors."""""""" This will include oversight of science, thematic goals, specimen allocation, personnel, finances and interactions. A project tracking system, interaction log and regular schedule of meetings and reviews insures productive high quality synergies between the three Projects and three Cores. These reviews and interactions include monthly web-based conferences, meetings with the Project and Core Leaders, interaction with Drs. Breakefield and Carter and Messer for thematic evaluation and definitions of end-points of study as well as consultations with the Internal Advisory committee members. Yearly review will be maintained by an External Advisory Board which will be convened. A portion of the Core B Biorepository will reside at the MGH under the aegis of Dr. Hochberg within Core A. (B). Neuropathologic oversight (Stemmer-Rachamimov) of veterinary studies (P1, Core C) and human studies as well as GBM cohorts resides within the Core A. (C). Statistical oversight resides in Core B (Messer) but local (Core A and Project 2,3) assistance is provided by Mrs. Muzikansky (Core A). The latter includes data sharing and pre-publication review. An experienced Scientific Program Manager will support Program Integration and Management by tracking Aims and agenda for monthly conferences.

Public Health Relevance

This Core will provide the cohesion and oversight critical for co-ordinating a multi-institutional effort to evaluate therapeutic initiatives and biomarkers for gliomas. This will serve to increase the relevance and rigor of findings from this P01 to maximize its impact on therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA069246-17
Application #
8657802
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
17
Fiscal Year
2014
Total Cost
$121,367
Indirect Cost
$28,430
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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