Abstract

EBV nucleic acids and antigens are commonly detected in association with the tumor cells of Hodgkin's disease. Abnormal immune function has long been recognized in patients with Hodgkin's disease but there has not yet been any systematic attempt to study EBV infection and the immune response to EBV in patients with Hodgkin's disease. We will study patients with newly diagnosed EBV(+) and EBV(-) Hodgkin's disease seen at the Joint Center for Radiation Therapy in Boston to determine: (i) the EBV load in peripheral blood lymphocytes, (ii) the CD8 cytotoxic immune response to a panel of EBV latency antigens expressed in Hodgkin's disease, (iii) the CD4 proliferative and cytokine responses to a panel of EBV latency antigens. This study will be the first comprehensive study of EBV and Hodgkin's disease, and will provide information crucial to characterizing the interplay between the viral infection, the immune system and tumorigenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA069266-03
Application #
6203357
Study Section
Project Start
1999-09-24
Project End
2000-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Levin, Lynn I; Breen, Elizabeth C; Birmann, Brenda M et al. (2017) Elevated Serum Levels of sCD30 and IL6 and Detectable IL10 Precede Classical Hodgkin Lymphoma Diagnosis. Cancer Epidemiol Biomarkers Prev 26:1114-1123
Epstein, Mara M; Chang, Ellen T; Zhang, Yawei et al. (2015) Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study. Am J Epidemiol 182:405-16
Li, Qian; Chang, Ellen T; Bassig, Bryan A et al. (2013) Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts. Cancer Causes Control 24:287-95
Gao, Yongshun; Li, Qian; Bassig, Bryan A et al. (2013) Subtype of dietary fat in relation to risk of Hodgkin lymphoma: a population-based case-control study in Connecticut and Massachusetts. Cancer Causes Control 24:485-94
Levin, Lynn I; Chang, Ellen T; Ambinder, Richard F et al. (2012) Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma. Blood 120:3750-5
Kasperzyk, Julie L; Chang, Ellen T; Birmann, Brenda M et al. (2011) Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. Am J Epidemiol 174:816-27
Chang, Ellen T; Birmann, Brenda M; Kasperzyk, Julie L et al. (2009) Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 18:976-86
Fu, De-Xue; Tanhehco, Yvette; Chen, Jianmeng et al. (2008) Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors. Nat Med 14:1118-22
Chang, Ellen T; Zheng, Tongzhang; Weir, Edward G et al. (2004) Childhood social environment and Hodgkin's lymphoma: new findings from a population-based case-control study. Cancer Epidemiol Biomarkers Prev 13:1361-70
Chang, Ellen T; Zheng, Tongzhang; Weir, Edward G et al. (2004) Aspirin and the risk of Hodgkin's lymphoma in a population-based case-control study. J Natl Cancer Inst 96:305-15

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