We propose to undertake cancer prevention studies that focus on both tobacco use behavior and dietary behavior. We will rely heavily on our already developed core expertise in telephone counselling and assessment and in biostatistical analysis. Our studies of tobacco use behavior are designed to further hasten the progress towards a smokefree society: Project One seeks to develop and test an effective intervention for those smokers who seek information on quitting but who are not ready to take the decisive step to quit Project 2 seeks to extend to adolescents our previous research in helping young adult smokers successfully quit. Project 3 extends our considerable work in using available data sets to understand the natural history of smoking behavior and to develop hypotheses for altering that behavior. In particular, this project will enable us to further test intervention hypotheses developed in Projects 1 and 2. We are interested in a role that diet may have in preventing or delaying secondary cancer events in women who have survived breast cancer. Our hypothesis is that a protective effect may occur from a dietary pattern that consists of the frequent ingestion of a wide variety of nutrients that have weak anticarcinogenic activity. Our goal is to undertake a randomized controlled trial of this dietary pattern hypothesis. Project 4 will extend our feasibility study demonstrating that we can achieve a significantly different dietary pattern among an ethnically diverse population and maintain that difference over time. We will look for early support for our hypothesis from the cancer event pattern in our two random groups. Project 5 is an analytic project that explores the relationship between self- reported dietary intakes and plasma carotenoid concentration in these groups of women and seeks to inform decisions on dietary guidelines in these cancer prevention studies.
| Proudfoot, James; Faig, Walter; Natarajan, Loki et al. (2018) A joint marginal-conditional model for multivariate longitudinal data. Stat Med 37:813-828 |
| Saquib, Nazmus; Stefanick, Marcia L; Natarajan, Loki et al. (2013) Mortality risk in former smokers with breast cancer: pack-years vs. smoking status. Int J Cancer 133:2493-7 |
| Saquib, Juliann; Parker, Barbara A; Natarajan, Loki et al. (2012) Prognosis following the use of complementary and alternative medicine in women diagnosed with breast cancer. Complement Ther Med 20:283-90 |
| Rief, Winfried; Bardwell, Wayne A; Dimsdale, Joel E et al. (2011) Long-term course of pain in breast cancer survivors: a 4-year longitudinal study. Breast Cancer Res Treat 130:579-86 |
| Gorman, Jessica R; Roesch, Scott C; Parker, Barbara A et al. (2010) Physical and mental health correlates of pregnancy following breast cancer. Psychooncology 19:517-24 |
| Gorman, Jessica R; Malcarne, Vanessa L; Roesch, Scott C et al. (2010) Depressive symptoms among young breast cancer survivors: the importance of reproductive concerns. Breast Cancer Res Treat 123:477-85 |
| Gorman, Jessica R; Usita, Paula M; Madlensky, Lisa et al. (2009) A qualitative investigation of breast cancer survivors' experiences with breastfeeding. J Cancer Surviv 3:181-91 |
| Madlensky, Lisa; Natarajan, Loki; Flatt, Shirley W et al. (2008) Timing of dietary change in response to a telephone counseling intervention: evidence from the WHEL study. Health Psychol 27:539-47 |
| Saquib, Nazmus; Flatt, Shirley W; Natarajan, Loki et al. (2007) Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women's healthy eating and living (WHEL) study. Breast Cancer Res Treat 105:177-86 |
| Johnson-Kozlow, Marilyn; Rock, Cheryl L; Gilpin, Elizabeth A et al. (2007) Validation of the WHI brief physical activity questionnaire among women diagnosed with breast cancer. Am J Health Behav 31:193-202 |
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