The goal of Core C is to provide scientific, administrative and statistical support for all of the Projects and Cores of the University of Washington Program on 'Human RecQ Helicases in Biology and Oncology'. Core C also provides a forum and mechanism for scientific review and decision-making, and promotes continuous, informal communication to facilitate research and collaboration within the Program and with outside investigators. We have incorporated and improved the most useful features of the Core with this revision, and added considerable new strength in biostatistical and computing support where our needs have continued to grow rapidly. The Core C Specific Aims are:
Aim 1 : Administrative support: Provide common administrative support for all Projects and Cores to facilitate Program budgeting, subcontract negotiation, purchasing and record-keeping, and Human Subjects and Animal approval filings;
Aim 2 : Scientific decision-making and planning: Provide centralized scientific decision-making to plan, facilitate and review research and to identify and develop new research directions;
Aim 3 : Resource development and sharing: Develop and share common research reagents, methods and resources across the Program as a whole;
Aim 4 : Biostatistical support: Provide common biostatistical support to facilitate experimental design, data mining and archiving, data analysis and publication;
and Aim 5 : RecQ web resource development/hosting: Develop web-accessible resources to facilitate research in RecQ helicase biology and medicine.

Public Health Relevance

This Core has been designed to provide administrative and statistical support to facilitate research in all of the Projects and Cores that constitute this research Program. The Program is focused on human RecQ helicase proteins and their roles in normal cells and in cancer pathogenesis and the response to chemotherapy.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-GRB-S)
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University of Washington
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Shiovitz, Stacey; Bertagnolli, Monica M; Renfro, Lindsay A et al. (2014) CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. Gastroenterology 147:637-45
Shen, Jiang-Cheng; Fox, Edward J; Ahn, Eun Hyun et al. (2014) A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval. Sci Rep 4:4894
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Kiianitsa, Kostantin; Maizels, Nancy (2014) Ultrasensitive isolation, identification and quantification of DNA-protein adducts by ELISA-based RADAR assay. Nucleic Acids Res 42:e108
Gray, Lucas T; Vallur, Aarthy C; Eddy, Johanna et al. (2014) G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD. Nat Chem Biol 10:313-8
Grady, William M; Pritchard, Colin C (2014) Molecular alterations and biomarkers in colorectal cancer. Toxicol Pathol 42:124-39

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