The goal of Core C is to provide scientific, administrative and statistical support for all of the Projects and Cores of the University of Washington Program on 'Human RecQ Helicases in Biology and Oncology'. Core C also provides a forum and mechanism for scientific review and decision-making, and promotes continuous, informal communication to facilitate research and collaboration within the Program and with outside investigators. We have incorporated and improved the most useful features of the Core with this revision, and added considerable new strength in biostatistical and computing support where our needs have continued to grow rapidly. The Core C Specific Aims are:
Aim 1 : Administrative support: Provide common administrative support for all Projects and Cores to facilitate Program budgeting, subcontract negotiation, purchasing and record-keeping, and Human Subjects and Animal approval filings;
Aim 2 : Scientific decision-making and planning: Provide centralized scientific decision-making to plan, facilitate and review research and to identify and develop new research directions;
Aim 3 : Resource development and sharing: Develop and share common research reagents, methods and resources across the Program as a whole;
Aim 4 : Biostatistical support: Provide common biostatistical support to facilitate experimental design, data mining and archiving, data analysis and publication;
and Aim 5 : RecQ web resource development/hosting: Develop web-accessible resources to facilitate research in RecQ helicase biology and medicine.

Public Health Relevance

This Core has been designed to provide administrative and statistical support to facilitate research in all of the Projects and Cores that constitute this research Program. The Program is focused on human RecQ helicase proteins and their roles in normal cells and in cancer pathogenesis and the response to chemotherapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA077852-15
Application #
8494587
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$77,667
Indirect Cost
$71,026
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Kehrli, Keffy; Phelps, Michael; Lazarchuk, Pavlo et al. (2016) Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest. J Biol Chem 291:24487-24503

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