The Administrative Core (Core A) provides centralized services that support the Principal Investigator, Project Leaders, and Core Resource Directors of the Program Project, and is responsible for continuity, coordination and oversight of the projects and support cores of the Program Project. The primary functions of the Core include the following: (a) provide direction and overall management of the Program;(b) foster communication and integration of the research projects and the cores by conducting regular scientific meetings of PPG investigators;(c) oversee and coordinate the efforts of the support cores by oversight committees and monitoring efficient usage;(d) monitor and track all expenditures of the PPG and ensure accurate allocation of funds;(e) provide logistics support for other aspects including personnel actions, IACUC documents, record keeping, progress reports;(f) arrange and coordinate meetings of the PPG internal and external scientific advisory boards, including travel. These Advisory groups will review progress of the entire Program, provide advice, and evaluate each project on at least a yearly basis. In addition, the Core will provide coordination and continuity to each of the projects and cores for the duration of the PPG. Stuart A. Aaronson, MD, will direct the Core with Ed Hicks, MBA, providing administrative and operational oversight. Ms. Donna Chiodi will provide general administrative assistance to all program project participants. The Core will operate out of the administrative suite of the Department of Oncological Sciences.
The overall relevance of this research Program is that major insights gained in the investigation of cellular stress responses involving p53 and understanding of the complex regulatory networks in which p53 acts offer the potential for improved therapeutic approaches to cancers as well as to other pathophysiologic conditions, which activate this central mediator of cell fate decisions.
|Pappas, Kyrie; Xu, Jia; Zairis, Sakellarios et al. (2017) p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Mol Cancer Res 15:1051-1062|
|Ou, Yang; Wang, Shang-Jui; Li, Dawei et al. (2016) Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A 113:E6806-E6812|
|Guernet, Alexis; Mungamuri, Sathish Kumar; Cartier, Dorthe et al. (2016) CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations. Mol Cell 63:526-38|
|Meslamani, Jamel; Smith, Steven G; Sanchez, Roberto et al. (2016) Structural features and inhibitors of bromodomains. Drug Discov Today Technol 19:3-15|
|Hwang, So-Young; Deng, Xianming; Byun, Sanguine et al. (2016) Direct Targeting of ?-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/?-Catenin Signaling. Cell Rep 16:28-36|
|Shi, D; Dai, C; Qin, J et al. (2016) Negative regulation of the p300-p53 interplay by DDX24. Oncogene 35:528-36|
|Tavana, Omid; Li, Dawei; Dai, Chao et al. (2016) HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med 22:1180-1186|
|Wang, Donglai; Kon, Ning; Lasso, Gorka et al. (2016) Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature 538:118-122|
|Mungamuri, Sathish Kumar; Qiao, Rui F; Yao, Shen et al. (2016) USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep 14:2528-37|
|Muñoz-Fontela, César; Mandinova, Anna; Aaronson, Stuart A et al. (2016) Emerging roles of p53 and other tumour-suppressor genes in immune regulation. Nat Rev Immunol 16:741-750|
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