Core B Pathology will provide services using histological, immunohistochemical, and immunofluorescence method on human neuroblastoma tissues and xenograft models for Project 1-3. Through this Core, services using confocal microscope will be available for analyzing immunofluorescence images. Core B also will utilize digital electron microscopy, when requested, on human and animal samples. Core leader will make a histopathology evaluation on human neuroblastoma cases according to the International Neuroblastoma Pathology Classification, and also provide the results of histology evaluation on bone marrow biopsies/aspirates from the patients for Project 4. During this project period, Core B pathology will establish Biorepository system and TMA for the high-risk human neuroblastoma tumor samples.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01CA081403-15
Application #
8677723
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Johnson, Brett E; Mazor, Tali; Hong, Chibo et al. (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189-93
Borriello, Lucia; DeClerck, Yves A (2014) [Tumor microenvironment and therapeutic resistance process]. Med Sci (Paris) 30:445-51
Gustafson, William Clay; Meyerowitz, Justin Gabriel; Nekritz, Erin A et al. (2014) Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell 26:414-27
Kang, Min H; Villablanca, Judith G; Glade Bender, Julia L et al. (2014) Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: a case report from a New Approaches to Neuroblastoma (NANT) Phase I study. BMC Res Notes 7:256
Solari, Valeria; Borriello, Lucia; Turcatel, Gianluca et al. (2014) MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival. Cancer Res 74:5999-6009
Sos, Martin L; Levin, Rebecca S; Gordan, John D et al. (2014) Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep 8:1037-48
Marshall, Glenn M; Carter, Daniel R; Cheung, Belamy B et al. (2014) The prenatal origins of cancer. Nat Rev Cancer 14:277-89
Ilkanizadeh, Shirin; Lau, Jasmine; Huang, Miller et al. (2014) Glial progenitors as targets for transformation in glioma. Adv Cancer Res 121:1-65
Bergfeld, Scott A; Blavier, Laurence; DeClerck, Yves A (2014) Bone marrow-derived mesenchymal stromal cells promote survival and drug resistance in tumor cells. Mol Cancer Ther 13:962-75
Chen, Justin; Weiss, William A (2014) When deletions gain functions: commandeering epigenetic mechanisms. Cancer Cell 26:160-1

Showing the most recent 10 out of 106 publications