This Program Project uses the rigorous paradigm of technology assessment to evaluate optical technologies and molecular imaging for the screening and diagnosis of cervical cancer. We will identify opportunities in which technology could improve outcomes, decrease costs, and replace infrastructure. Optical measurement of tissue provides quantitative information that can be analyzed, instantaneously producing an objective diagnosis even in the hands of a non-expert operator. We 'will conduct multi-center clinical trials to assess the screening and diagnostic potential of several emerging technologies: a fluorescence/reflectance point probe, a multispectral digital colposcope, confocal microscopy, and new contrast agents to mark cervical lesions that may be used in combination with other devices. This Program Project will also develop and evaluate a system that combines a point probe with multispectral imaging, and we will create low-cost, portable imaging devices that are optimized to meet healthcare needs in the developing world and underserved areas of the United States. Specifically, we will measure the sensitivity, specificity, cost-effectiveness, degree of patient discomfort, time-to-result, and training requirements associated with new instruments and techniques. We will compare these systems to the standard-of-care and to each other to find optimized solutions for low- and high-resource settings. We maintain a pipeline of innovation that brings devices from the laboratory bench to the bedside. Although new HPV vaccines may eventually have a strong impact on cervical cancer incidence, the biological limitations of current vaccines and the logistical difficulty associated with universal mass vaccination programs mean that early detection will remain our best defense against cervical cancer for the foreseeable future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA082710-10
Application #
8127946
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (O1))
Program Officer
Nordstrom, Robert J
Project Start
1999-09-23
Project End
2012-07-31
Budget Start
2011-08-22
Budget End
2012-07-31
Support Year
10
Fiscal Year
2011
Total Cost
$2,431,163
Indirect Cost
Name
Drexel University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Yamal, Jose-Miguel; Guillaud, Martial; Atkinson, E Neely et al. (2015) Prediction using hierarchical data: Applications for automated detection of cervical cancer. Stat Anal Data Min 8:65-74
Montealegre, Jane R; Landgren, Rachel M; Anderson, Matthew L et al. (2015) Acceptability of self-sample human papillomavirus testing among medically underserved women visiting the emergency department. Gynecol Oncol 138:317-22
Davies, Kalatu R; Cantor, Scott B; Cox, Dennis D et al. (2015) An alternative approach for estimating the accuracy of colposcopy in detecting cervical precancer. PLoS One 10:e0126573
Nghiem, V T; Davies, K R; Beck, J R et al. (2015) Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening. Br J Cancer 112:1951-7

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