The patient's perspective on the acceptability of technological innovation must be taken into account during the development of new technologies. Because patients are involved in their own care, medical devices that address their needs can produce better treatment outcomes. In this program project, we take a global approach to developing and assessing technologies to detect cervical cancer, considering factors at all levels that affect cervical screening and diagnosis: from the molecular to the patients and their communities. In Project 4, we will consider the effects of emerging technologies on patient outcomes in both developed and developing worlds. In developed countries, the multiple delays in the diagnosis and treatment trajectory after Papanicolaou smear and biopsy can reduce adherence and increase psychological distress for women receiving unfavorable results. In developing countries and underserved areas of the developed world, standard-of-care procedures require resources that are not available. In addition, cultural beliefs about screening for cervical cancer often exist that pose barriers to widespread screening programs. In this program project, we are developing technologies to address limitations in current technologies for both developed and developing countries. Emerging technologies under development with support from this grant aim to improve screening outcomes through (1) improved accuracy in less time, which can support diagnosis and treatment in a single visit;(2) more automation, facilitating wider use of the technology by non-expert providers;and (3) less invasive testing, which results in increased comfort and less distress for patients. To achieve the goals of Project 4, we take surveys of patient attitudes, distress, anxiety, pain, and priorities from 805 participants in the two clinical trials proposed in Project 3, which will be conducted at six clinical sites in Vancouver and Houston. We will also assess specific barriers to health care delivery in Appalachia, the Texas-Mexico border, and in Ibadan, Nigeria.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
7P01CA082710-11
Application #
8379186
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
11
Fiscal Year
2012
Total Cost
$311,984
Indirect Cost
$19,001
Name
Texas Tech University
Department
Type
DUNS #
609980727
City
Lubbock
State
TX
Country
United States
Zip Code
79430
Montealegre, J R; Peckham-Gregory, E C; Marquez-Do, D et al. (2017) Racial/ethnic differences in HPV 16/18 genotypes and integration status among women with a history of cytological abnormalities. Gynecol Oncol :
Zhu, Hongxiao; Morris, Jeffrey S; Wei, Fengrong et al. (2017) Multivariate functional response regression, with application to fluorescence spectroscopy in a cervical pre-cancer study. Comput Stat Data Anal 111:88-101
Yang, Jingjing; Cox, Dennis D; Lee, Jong Soo et al. (2017) Efficient Bayesian hierarchical functional data analysis with basis function approximations using Gaussian-Wishart processes. Biometrics 73:1082-1091
Nghiem, Van T; Davies, Kalatu R; Beck, J Robert et al. (2016) Overtreatment and Cost-Effectiveness of the See-and-Treat Strategy for Managing Cervical Precancer. Cancer Epidemiol Biomarkers Prev 25:807-14
Nghiem, Van T; Davies, Kalatu R; Chan, Wenyaw et al. (2016) Disparities in cervical cancer survival among Asian-American women. Ann Epidemiol 26:28-35
Sheikhzadeh, Fahime; Ward, Rabab K; Carraro, Anita et al. (2015) Quantification of confocal fluorescence microscopy for the detection of cervical intraepithelial neoplasia. Biomed Eng Online 14:96
Yamal, Jose-Miguel; Guillaud, Martial; Atkinson, E Neely et al. (2015) Prediction using hierarchical data: Applications for automated detection of cervical cancer. Stat Anal Data Min 8:65-74
Montealegre, Jane R; Landgren, Rachel M; Anderson, Matthew L et al. (2015) Acceptability of self-sample human papillomavirus testing among medically underserved women visiting the emergency department. Gynecol Oncol 138:317-22
Davies, Kalatu R; Cantor, Scott B; Cox, Dennis D et al. (2015) An alternative approach for estimating the accuracy of colposcopy in detecting cervical precancer. PLoS One 10:e0126573
Nghiem, V T; Davies, K R; Beck, J R et al. (2015) Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening. Br J Cancer 112:1951-7

Showing the most recent 10 out of 108 publications