The patient's perspective on the acceptability of technological innovation must be taken into account during the development of new technologies. Because patients are involved in their own care, medical devices that address their needs can produce better treatment outcomes. In this program project, we take a global approach to developing and assessing technologies to detect cervical cancer, considering factors at all levels that affect cervical screening and diagnosis: from the molecular to the patients and their communities. In Project 4, we will consider the effects of emerging technologies on patient outcomes in both developed and developing worlds. In developed countries, the multiple delays in the diagnosis and treatment trajectory after Papanicolaou smear and biopsy can reduce adherence and increase psychological distress for women receiving unfavorable results. In developing countries and underserved areas of the developed world, standard-of-care procedures require resources that are not available. In addition, cultural beliefs about screening for cervical cancer often exist that pose barriers to widespread screening programs. In this program project, we are developing technologies to address limitations in current technologies for both developed and developing countries. Emerging technologies under development with support from this grant aim to improve screening outcomes through (1) improved accuracy in less time, which can support diagnosis and treatment in a single visit;(2) more automation, facilitating wider use of the technology by non-expert providers;and (3) less invasive testing, which results in increased comfort and less distress for patients. To achieve the goals of Project 4, we take surveys of patient attitudes, distress, anxiety, pain, and priorities from 805 participants in the two clinical trials proposed in Project 3, which will be conducted at six clinical sites in Vancouver and Houston. We will also assess specific barriers to health care delivery in Appalachia, the Texas-Mexico border, and in Ibadan, Nigeria.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brookdale University Hospital & Medical Center
United States
Zip Code
Li, Gerald; van Niekerk, Dirk; Miller, Dianne et al. (2014) Molecular fixative enables expression microarray analysis of microdissected clinical cervical specimens. Exp Mol Pathol 96:168-77
Scheurer, Michael E; Danysh, Heather E; Follen, Michele et al. (2014) Association of traffic-related hazardous air pollutants and cervical dysplasia in an urban multiethnic population: a cross-sectional study. Environ Health 13:52
Wang, Lu; Lee, Jong Soo; Lane, Pierre et al. (2014) A statistical model for removing inter-device differences in spectroscopy. Opt Express 22:7617-24
Montealegre, Jane R; Zhou, Renke; Amirian, E Susan et al. (2014) Uncovering nativity disparities in cancer patterns: Multiple imputation strategy to handle missing nativity data in the Surveillance, Epidemiology, and End Results data file. Cancer 120:1203-11
Guillaud, Martial; Buys, Timon P H; Carraro, Anita et al. (2014) Evaluation of HPV infection and smoking status impacts on cell proliferation in epithelial layers of cervical neoplasia. PLoS One 9:e107088
Montealegre, Jane R; Zhou, Renke; Amirian, E Susan et al. (2013) Nativity disparities in late-stage diagnosis and cause-specific survival among Hispanic women with invasive cervical cancer: an analysis of Surveillance, Epidemiology, and End Results data. Cancer Causes Control 24:1985-94
Yang, Jingjing; Scott, David W (2013) Robust Fitting of a Weibull Model with Optional Censoring. Comput Stat Data Anal 67:149-161
El Hallani, S; Poh, C F; Macaulay, C E et al. (2013) Ex vivo confocal imaging with contrast agents for the detection of oral potentially malignant lesions. Oral Oncol 49:582-90
Montgomery, Owen; Follen, Michele; Urdaneta-Hartmann, Sandra (2012) The 2010 Annual Sex and Gender Research Forum at Drexel University and Drexel University College of Medicine: an institute for women's health and leadership initiative. Introduction. Gend Med 9:S1-6
Pham, Bryan; Rhodes, Helen; Milbourne, Andrea et al. (2012) Epidemiologic differentiation of diagnostic and screening populations for the assessment of cervical dysplasia using optical technologies. Gend Med 9:S36-47

Showing the most recent 10 out of 90 publications