The Biological Models, Molecular Pathology and Biostatistics Core will provide services and perform research to achieve the goals of the Program. By housing these three biological areas of research and service within a single core, we can standardize and validate the assaysand methods used in the various projects to insure meaningful interpretation of the wide array of data obtained.
The aims of the three arms of this Core are as follows. For the Biological Models arm, the aims are to develop and then provide to investigators novel biological models for the study of pancreatic cancer and non-melanoma skin cancers. Our extensive experience with orthotopic models (localized prostate Ca, metastatic colon Ca, disseminated ovarian Ca, and chemically induced oral Ca) forms the basis for establishing in vivo and in vitro 3D culture models for pancreatic cancer, and organotypic models for skin cancer. The goals of the Molecular Pathology & Microscopy arm will be achieved in 3 aims:
Aim 1 will provide histology services, Aim 2 will provide the molecular profiling of PDT response of cancer cells, and Aim 3 will provide the quantification of biomarkers for translational research in the form of tissue banking of specimens from the clinical projects. This is a research component of the Core and involves the identification of novel cancer biomarkers for diagnosis, prognosis, and for the monitoring of treatment response. Once the biomarkers are characterized, the Core will provide their quantification as a service, to investigators. The Core has extensive expertise in histopathology acquired during the previous funding period, and is able to provide histology services to projects in a timely and cost- effective fashion. The Biostatistics arm has two functions: (1) to facilitate data sharing between projects, and (2) to assist with statistical design and analysis for the projects. To facilitate data sharing between investigators from different sites, the Core will maintain databases;in collaboration with Core A, these will be posted on the Program website. Finally, the Core will offer the resources of a statistician to advise Projects at every stage (on experimental design, collection, and interpretation of results). The Program, throughpre- clinical and clinical studies, will develop novel treatment options for pancreatic and skin cancers. The Cores are essential components for the successful completion of the Projects in this Program. Furthermore, the Core will benefit public health in two major ways: (1) by providing the basis for future patient selection for treatment with PDT, (2) by data sharing with the scientific community wherever possible, human tissues characterized for relevant biomarkers with diagnostic or prognostic values for optimized molecule-based combination therapy strategies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1)
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Massachusetts General Hospital
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Bulin, Anne-Laure; Broekgaarden, Mans; Hasan, Tayyaba (2017) Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids. Sci Rep 7:16645
de Souza, Ana Luiza Ribeiro; LaRochelle, Ethan; Marra, Kayla et al. (2017) Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ. Photodiagnosis Photodyn Ther 20:227-233
Wang, Hexuan; Nieskoski, Michael D; Marra, Kayla et al. (2017) Elastographic Assessment of Xenograft Pancreatic Tumors. Ultrasound Med Biol 43:2891-2903
Nieskoski, Michael D; Marra, Kayla; Gunn, Jason R et al. (2017) Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer. Sci Rep 7:10093
Pereira, S P; Goodchild, G; Webster, G J M (2017) The endoscopist and malignant and non-malignant biliary obstruction. Biochim Biophys Acta :
Obaid, Girgis; Spring, Bryan Q; Bano, Shazia et al. (2017) Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery. J Biomed Opt 22:1-6
Mlacker, Stephanie; Kaw, Urvashi; Maytin, Edward V (2017) Use of photodynamic therapy and acitretin in generalized eruptive keratoacanthoma of Grzybowski. JAAD Case Rep 3:457-459
Anand, Sanjay; Rollakanti, Kishore R; Brankov, Nikoleta et al. (2017) Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death. Mol Cancer Ther 16:1092-1101
Keane, Margaret G; Shah, Amar; Pereira, Stephen P et al. (2017) Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy. F1000Res 6:1643
Lee, Han Hee; Choi, Myung-Gyu; Hasan, Tayyaba (2017) Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? Korean J Intern Med 32:1-10

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