The Administrative Core supports the administrative functions for all three projects and the Biospecimen core. There are five Specific Aims as follows: 1. Administer financial aspects of the program. 2. Provide logistical support for publications, presentations, and travel. 3. Facilitate communication and cooperation between the projects and participants. 4. Facilitate communication between the program as a whole and the internal/external advisors. 5. Assist in arranging lectures related to prostate cancer by inside and outside experts. Each of these Aims is critical to the overall function of this program project.
In Aim #1 the Core will provide timely financial reporting to the project and core investigators and assist in budgetary decisions. It will be intimately involved in the annual Progress Report to NIH.
In Aim #2, the Core provides the infrastructure support for publications and travel to national meetings. One trip per year is provided for each project/core leader in the Admistrative Core budget.
Aim #3 is constantly ongoing as it facilitates the scheduled and spontaneous meetings of the investigative team. This includes workshops, seminars, and the multiple research group meetings.
In Aim #4, the Core will assure that members of the Internal and External Advisory Boards are kept up to date with progress of the investigators. For the External Advisory Board members this will occur once per year at the annual Progress Report Meeting. For the Internal Advisory Board members this occurs not only at this annual meeting but also periodically during the year. Finally, in Aim #5 the Core further endeavors to increase communication among the program project investigators by assisting with selection of guest speakers in the field of prostate cancer. This component is conducted in alliance with the Administrative Core of the NW Prostate Cancer SPORE which has a similar intent in bringing guest speakers to Seattle.

Public Health Relevance

The Administrative Core is not scientifically driven but is essential for the functional organization of the overall Program Project. It facilitates many aspects critical to the investigative team so that they can perform their studies in an efficient and cost-effective manner.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Damodarasamy, Mamatha; Vernon, Robert B; Chan, Christina K et al. (2015) Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation. In Vitro Cell Dev Biol Anim 51:50-8
Long, Thomas J; Sprenger, Cynthia C; Plymate, Stephen R et al. (2014) Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape. Biomaterials 35:8164-74
Chéry, Lisly; Lam, Hung-Ming; Coleman, Ilsa et al. (2014) Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways. Oncotarget 5:9939-51
Lucas, Jared M; Heinlein, Cynthia; Kim, Tom et al. (2014) The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov 4:1310-25
Gordon, Ryan R; Wu, Mengchu; Huang, Chung-Ying et al. (2014) Chemotherapy-induced monoamine oxidase expression in prostate carcinoma functions as a cytoprotective resistance enzyme and associates with clinical outcomes. PLoS One 9:e104271
Tang, Xi; Mahajan, Sumit S; Nguyen, Liem T et al. (2014) Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget 5:1352-62
Vela, I; Morrissey, C; Zhang, X et al. (2014) PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer. Clin Exp Metastasis 31:199-211
Chevillet, John R; Kang, Qing; Ruf, Ingrid K et al. (2014) Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci U S A 111:14888-93
Thadani-Mulero, Maria; Portella, Luigi; Sun, Shihua et al. (2014) Androgen receptor splice variants determine taxane sensitivity in prostate cancer. Cancer Res 74:2270-82
Yu, X; Cates, J M; Morrissey, C et al. (2014) SOX2 expression in the developing, adult, as well as, diseased prostate. Prostate Cancer Prostatic Dis 17:301-9

Showing the most recent 10 out of 118 publications