Core A is responsible for cohort follow-up and database maintenance in the Nurses'Health Study.
The specific aims for this core are as follows: 1) Develop and mail biennial follow-up questionnaires to cohort participants 2) Process returned questionnaires and verify responses 3) Compile databases of exposure data 4) Trace lost participants and maintain an updated name and address file 5) Sustain high cohort participation Under the direction of Diane Feskanich, ScD, Core A develops and designs the questionnaire for biennial follow-up of study participants. Questionnaire design incorporates input from all investigators on the Program Project, as well as other collaborating investigators, through bi-weekly meetings. New questions are pilot tested and follow-up methods are refined to address the needs of the cohort members. Returned questionnaires are checked for completeness, optically scanned, and verified for errors. Over 80,000 questionnaires are returned in every follow-up cycle. Core A uses a range of methods to trace participants and to maintain a high 90% response rate. Returned questionnaires are digitally imaged and stored on DVD, from which they are easily retrievable. Exposure data from the questionnaires are complied into databases and variables are derived and documented for use by investigators. This includes maintenance of nutrient intakes derived from the food frequency portion of the questionnaire. Diseases reported on the questionnaires are passed to Core B for confirmation.

Public Health Relevance

Core A activities are critical for gathering exposure and disease information and for maintaining follow-up in the Nurses'Health Study and hence for maintaining the validity of all analyses conducted in Projects 1-4. By extension, this Core is vital to our ability to find ways to prevent cancer Incidence and improve survival in women.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Sisti, Julia S; Collins, Laura C; Beck, Andrew H et al. (2016) Reproductive risk factors in relation to molecular subtypes of breast cancer: Results from the nurses' health studies. Int J Cancer 138:2346-56
Yuan, Chen; Clish, Clary B; Wu, Chen et al. (2016) Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. J Natl Cancer Inst 108:djv409
Li, W-Q; Han, J; Cho, E et al. (2016) Personal history of psoriasis and risk of incident cancer among women: a population-based cohort study. Br J Dermatol 174:1108-11
Mima, Kosuke; Nishihara, Reiko; Nowak, Jonathan A et al. (2016) MicroRNA MIR21 and T Cells in Colorectal Cancer. Cancer Immunol Res 4:33-40
Carreras-Torres, Robert; Haycock, Philip C; Relton, Caroline L et al. (2016) The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study. Sci Rep 6:31121
Poole, Elizabeth M; Kubzansky, Laura D; Sood, Anil K et al. (2016) A prospective study of phobic anxiety, risk of ovarian cancer, and survival among patients. Cancer Causes Control 27:661-8
Yang, M; Hu, F B; Giovannucci, E L et al. (2016) Nut consumption and risk of colorectal cancer in women. Eur J Clin Nutr 70:333-7
Earp, Madalene; Winham, Stacey J; Larson, Nicholas et al. (2016) A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget 7:7381-9
Song, Mingyang; Giovannucci, Edward (2016) Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States. JAMA Oncol 2:1154-61
Yakoob, Mohammad Y; Shi, Peilin; Willett, Walter C et al. (2016) Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two Large Prospective Cohorts. Circulation 133:1645-54

Showing the most recent 10 out of 1498 publications